Results 91 to 100 of about 1,808,025 (321)

Overcoming the translational roadblocks: a cancer care and research model

Clinical and Translational Medicine, 2014
There are many challenges to the process of translating the knowledge gained in the laboratory into new clinical approaches that can meet the needs of patients, clinicians and the wider community. We describe here an initiative that has borrowed concepts
Lauren Braun, Helena ML Daudt, Peter Watson   +2 more
doaj   +1 more source

Translational research on advanced therapies

Annali dell'Istituto Superiore di Sanità, 2011
Fostering translational research of advanced therapies has become a major priority of both scientific community and national governments. Advanced therapy medicinal products (ATMP) are a new medicinal product category comprising gene therapy and cell ...
Filippo Belardelli, Paola Rizza, Franca Moretti, Cintia Carella, Maria Cristina Galli, Giovanni Migliaccio   +5 more
doaj   +1 more source

Service-Learning Mini-Institute Agenda [PDF]

, 2014
Service-Learning Mini-Institute Agenda. Day 1: Introduction to Service-Learning.
VCU Center for Clinical and Translational Research, VCU Division of Community Engagement   +1 more
core   +1 more source

‘Translating Cultures’, translating research

, 2017
In this article, Charles Forsdick, AHRC Theme Leadership Fellow for ‘Translating Cultures’, presents the policy issues revealed and addressed by research carried out under the theme, and highlights the challenges and potential of ‘translating’ academic research to policymakers.
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Alzheimer’s Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research [PDF]

, 2020
Francesca Pistollato, Camilla Bernasconi, Janine McCarthy, Ivana Campia, Christian Desaintes, Clemens Wittwehr, Pierre Deceuninck, Maurice Whelan   +7 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

From extinction learning to anxiety treatment: mind the gap [PDF]

, 2019
Laboratory models of extinction learning in animals and humans have the potential to illuminate methods for improving clinical treatment of fear-based clinical disorders.
Carpenter, Joseph K., Hofmann, Stefan G., Pinaire, Megan   +2 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Biomarkers in emergency medicine [PDF]

, 2018
Researchers navigate the ocean of biomarkers searching for proper targets and optimal utilization of them. Emergency medicine builds up the front line to maximize the utility of clinically validated biomarkers and is the cutting edge field to test the ...
Cardelli, P., Hur, M., Somma, S. D.
core   +2 more sources