Results 81 to 90 of about 1,837,633 (293)

Disparities in registration and use of an online patient portal among older adults: findings from the LitCog cohort [PDF]

, 2015
(C) The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved.Financial disclosure: This project was supported by the National Institute on Aging (R01 AG030611), the National ...
Alsabbagh, Ancker, Bailey, Baker, Bender, Berkman, Blumenthal, Cho, Chrischilles, Eklund, Goel, Goel, Goldzweig, Haggstrom, Hsiao, Jung, Krist, Laura M Curtis, Levine, Lyles, Maat, Mayberry, Michael S Wolf, Mishuris, Mita Sanghavi Goel, Mossberger, Norman, Osborn, Paasche-Orlow, Pandey, Rachel O’Conor, Ralston, Samuel G Smith, Sarkar, Sarkar, Sarkar, Smith, Tang, Tom, Turvey, Viswanath, Wade-Vuturo, Wallston, Weiss, Weppner, William Aitken, Wolf, Zell, Zhang, Zickmund   +49 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Intracerebral hemorrhage in translational research

Brain Hemorrhages, 2020
Intracerebral hemorrhage (ICH) is a serious stroke subtype with high morbidity and mortality. The prognosis of ICH is poor. In recent years, there have been many studies on how to improve the prognosis of ICH.
Ruiyi Zhang, Qian Bai, Yang Liu, Yan Zhang, Zhaofu Sheng, Mengzhou Xue, V. Wee Yong   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Price of Progress: Funding and Financing Alzheimer\u27s Disease Drug Development [PDF]

, 2018
Introduction Advancing research and treatment for Alzheimer\u27s disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding ...
Cummings, Jeffrey, Kumar, Parvesh, Reiber, Carl   +2 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Overcoming the translational roadblocks: a cancer care and research model

Clinical and Translational Medicine, 2014
There are many challenges to the process of translating the knowledge gained in the laboratory into new clinical approaches that can meet the needs of patients, clinicians and the wider community. We describe here an initiative that has borrowed concepts
Lauren Braun, Helena ML Daudt, Peter Watson   +2 more
doaj   +1 more source

Translational research on advanced therapies

Annali dell'Istituto Superiore di Sanità, 2011
Fostering translational research of advanced therapies has become a major priority of both scientific community and national governments. Advanced therapy medicinal products (ATMP) are a new medicinal product category comprising gene therapy and cell ...
Filippo Belardelli, Paola Rizza, Franca Moretti, Cintia Carella, Maria Cristina Galli, Giovanni Migliaccio   +5 more
doaj   +1 more source

‘Translating Cultures’, translating research

, 2017
In this article, Charles Forsdick, AHRC Theme Leadership Fellow for ‘Translating Cultures’, presents the policy issues revealed and addressed by research carried out under the theme, and highlights the challenges and potential of ‘translating’ academic research to policymakers.
openaire   +2 more sources

Roadblocks to translational challenges on viral pathogenesis. [PDF]

, 2013
Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven, Drosten, Christian, Picker, Louis, Subbarao, Kanta, Suzich, Joann   +4 more
core   +1 more source