Results 91 to 100 of about 1,837,633 (293)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Parkinson’s disease and translational research

Translational Neurodegeneration, 2020
Parkinson’s disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications.
Elisabeth Dinter, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann, Björn H. Falkenburger   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Institutional shared resources and translational cancer research [PDF]

, 2009
The development and maintenance of adequate shared infrastructures is considered a major goal for academic centers promoting translational research programs.
Paolo De Paoli, W Hait, JS Pober, C Slaughter, RH Angeletti, J Howells, KI Berns, J Mestas, J Schnabel, MC Pierce, EB Brown, GJ Kelloff, S Ke, D Dominguez-Sola, JA Conchello, YD Mahnke, SP Perfetto, DW Stacey, PO Kutzik, SE Schakney, JM Irish, FE Craig, SD Freeman, F Kern, LA Sklar, JP Nolan, N Sachdeva, J Lu, M Eisenstein, SF Ibrahim, LA Johnson, LS Cram, CH Chung, J Quackenbush, N Rosenfeld, S Michiels, RA Irizarry, CL Yauk, A de Reynies, JK Cowell, RL Strausberg, J Shendure, MR Speicher, MB Lambros, BL Hsi, A Kallioniemi, JP Maciejewsi, A Mortazavi, J Shendure, A Rhoades, RL Camp, CB Moeder, SA Tomlins, D Voduc, SR Owens, CM Perou, V Espina, AS Rodrigues, M Hergenhahn, W Kolch, EF Petrocoin, J Lin, GS Omenn, J Wulfkuhle, JW Hager, E Gorelik, S Pelech, KK Frese, T van Dyke, D Hanahan, JS Lewis, R Weissleder, KP Olive, AR Kherlopian, MJ Pittet, HAT Nyman, PH Riegman, MM Morente, RO Barnes, International Society for Biological and Environmental Repositories, EB van Veen, P De Paoli, SJ Qualman, M Yuille, E Pukkala, R Tedeschi, K Knox, E Zika, JH Moore, MS Boguski, O Ermolaeva, M Kanehisa, R Simon, G Gomez-Lopez, DX Nguyen, KC Anderson, SL George, AJ Vickers, K Owzar, OI Olopade, G Tortora, PS Steeg, A Hurria, P Workman, AD Roses, WP Yong, American Society of Clinical Oncology, DM Dilts, LA Zwelling, H Moses, SA Plotkin, MM Davis, DH Hamilton, D Chaussabel, TS Heng, DM Girnita, DE Zak, AP Gee, P Rebulla, DH McKenna, SK Liu   +120 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Taking the Translational Science Benefits Model from concept to operationalization: opportunities and challenges in defining impact using the Translational Science Benefits Model

Frontiers in Public Health
The Translational Science Benefits Model (TSBM) was developed to conceptualize and communicate the benefits and impact of translational research. While the TSBM was developed as a conceptual model rather than an operational process, it can be integrated ...
Jessica Sperling, Jessica Sperling, Eman Ghanem, Stella Quenstedt, Tarun Saxena   +4 more
doaj   +1 more source

An annotation scheme and gold standard for Dutch-English word alignment [PDF]

, 2010
The importance of sentence-aligned parallel corpora has been widely acknowledged. Reference corpora in which sub-sentential translational correspondences are indicated manually are more labour-intensive to create, and hence less wide-spread.
Macken, Lieve
core  

Trends in Alcoholic Hepatitis-related Hospitalizations, Financial Burden, and Mortality in the United States [PDF]

, 2015
BACKGROUND: Alcoholic hepatitis (AH) is the most florid manifestation of alcoholic liver disease which accounts for significant morbidity, mortality, and financial burden.
Jinjuvadia, Raxitkumar, Liangpunsakul, Suthat, Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium   +2 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source