Results 71 to 80 of about 1,837,633 (293)

Human and animal models for translational research on neurodegeneration: Challenges and opportunities from South America [PDF]

, 2018
Facing the alarming growth of dementia and neurodegenerative conditions has become a critical priority across the globe (Alzheimer´s Disease International, 2009;Lancet, 2015;Shah et al., 2016;Parra et al., 2018).
Cogram, Patricia, Deacon, Robert, García, Adolfo Martín, Ibañez, Agustin Mariano, Sedeño, Lucas   +4 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Survey Study of Roadblocks in Translational Science

Clinical and Translational Science
Clinical and translational science needs to address roadblocks to the translational processes. We conducted a survey at two institutions, a private medical school and a large public university, to understand the frequency and distribution of barriers and
Fasiha Kanwal, Christopher I. Amos, Katherine H. Sippel, Claudia Neuhauser, Ariel Harrison, Mary E. Dickinson, Charles Minard, Bettina M. Beech   +7 more
doaj   +1 more source

Translational research in psychiatry

Industrial Psychiatry Journal
Translational research in psychiatry bridges the gap between basic scientific discoveries and clinical applications, aiming to improve the diagnosis, treatment, and prevention of mental illnesses.
Vinay Singh Chauhan, Markanday Sharma
doaj   +1 more source

Mesothelioma and thymic tumors: Treatment challenges in (outside) a network setting [PDF]

, 2019
The management of patients with mesothelioma and thymic malignancy requires continuous multidisciplinary expertise at any step of the disease. A dramatic improvement in our knowledge has occurred in the last few years, through the development of ...
Girard, N, Grassino, M, Imbimbo, M, Maury, J, Vitale, F   +4 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Bioinformatics advances in saliva diagnostics [PDF]

, 2012
There is a need recognized by the National Institute of Dental & Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base (SKB) is to create
B Smith, Barry Smith, C Phillips, CM Huang, DA Natale, David TW Wong, DP Ng, E Birney, I Garcia, I Takeda, J Ai, Ji-Ye Ai, JM Guberman, K Degtyarenko, M Ashburner, P Grenon, RR Brinkman, S Hu   +17 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A team-based translational journal club: Understanding the translational research highway

Journal of Clinical and Translational Science, 2019
The mission of the National Center for Advancing Translational Science (NCATS) is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a ...
Carol Feghali-Bostwick, Jillian Harvey, Carissa Hasseler, Diana Lee-Chavarria, Perry Halushka   +4 more
doaj   +1 more source