Results 71 to 80 of about 51,482,470 (263)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Translational Research Part 2

, 2017
Week 2: Translational Research and Big Data 2.2 Translational Research Translational Research Lecture Part 2Demystifying Biomedical Big Data BIOX-201 ...
Haddad, Bassem, Gusev, Yuriy, McGarvey, Peter   +2 more
core  

Preventing Translational Scientists From Extinction: The Long-Term Impact of a Personalized Training Program in Translational Medicine on the Careers of Translational Scientists

Frontiers in Medicine, 2018
Far too much biomedical research is wasted and ends in the so called “Valley of Death”: the gap that exists between biomedical research and its clinical application. While the translational process requires collaboration between many disciplines, current
Margot M. Weggemans, Marieke van der Schaaf, Manon Kluijtmans, Manon Kluijtmans, Janet P. Hafler, Janet P. Hafler, Norman D. Rosenblum, Norman D. Rosenblum, Berent J. Prakken, Berent J. Prakken   +9 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Taking Flight to Disseminate Translational Research: A Partnership between the UMass Center for Clinical and Translational Science and the Library’s Institutional Repository [PDF]

, 2017
eScholarship@UMMS is the University of Massachusetts Medical School’s open access digital archive of research and scholarship, managed by the Lamar Soutter Library.
Gore, Sally A., Palmer, Lisa A.
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Sustainability considerations for clinical and translational research informatics infrastructure [PDF]

, 2018
A robust biomedical informatics infrastructure is essential for academic health centers engaged in translational research. There are no templates for what such an infrastructure encompasses or how it is funded.
Barnett, William K, Obeid, Jihad S., Knosp, Boyd, Anderson, Nicholas R, McIntosh, Leslie D, Bell, Douglas S., Harris, Paul A, Tachinardi, Umberto, Cimino, James J, Hogan, William R., Obeid, Jihad S, McIntosh, Leslie D., Harris, Paul A., Cimino, James J., Embi, Peter J., Bell, Douglas S, Barnett, William K., Hogan, William R, Anderson, Nicholas R., Tarczy-Hornoch, Peter, Embi, Peter J, Wehbe, Firas H, Wehbe, Firas H.   +22 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source