Results 31 to 40 of about 51,482,470 (263)

Solving the riddle of codon usage preferences: a test for translational selection [PDF]

, 2004
Translational selection is responsible for the unequal usage of synonymous codons in protein coding genes in a wide variety of organisms. It is one of the most subtle and pervasive forces of molecular evolution, yet, establishing the underlying causes ...
Savva, Renos, Wernisch, Lorenz, dos Reis, M.   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Translational PET imaging research

Neurobiology of Disease, 2014
The goal of any early central nervous system (CNS) drug development program is always to test the mechanism and not the molecule in order to support additional research investments in late phase clinical trials.
Richard J. Hargreaves, Eugenii A. Rabiner   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

2A peptides provide distinct solutions to driving stop-carry on translational recoding [PDF]

, 2011
Funded by the U.K. Biotechnology and Biological Sciences Research Council (BB/E/01070911)Expression of viral proteins frequently includes non-canonical decoding events (‘recoding’) during translation. ‘2A’ oligopeptides drive one such event, termed ‘stop-
Yan, F, Doronina, V, Jeremy D. Brown, Fu Yan, Ryan, Martin D, Brown, Jeremy D, Escuin-Ordinas, Helena, Martin D. Ryan, Doronina, Victoria A, Ryan, Martin Denis, Sharma, Pamila, Sharma, P, Brown, Jeremy, Yan, Fu, Helena Escuin-Ordinas, Pamila Sharma, Victoria A. Doronina   +16 more
core   +1 more source

Taurine as a biomarker for aging: A new avenue for translational research

Advances in Biomarker Sciences and Technology, 2023
The physiologic and irreversible process of ageing is accompanied by a wide range of structural and functional shifts at multiple different levels.
Animesh Acharjee
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Behavioural phenotypes: working towards translational research through research partnerships [PDF]

, 2018
The 21st International Symposium of the Society for the Study of Behavioural Phenotypes (SSBP) takes place in Melbourne, Australia, this year. This edition of JIDR features abstracts from this meeting, highlighting the diverse range of researchers that ...
D. Adams, Gray, KM, H. Heussler, Heussler, H, Adams, D, K. M. Gray   +5 more
core   +1 more source

Enhancing translational medical research through proof-of-concept services: clinicians’ perspectives

Scientific Reports
Although the proof-of-concept (POC) phase is critical for the success of translational medical research (TMR), its use remains limited, and clinicians are frequently uncertain about how to seek assistance from POC teams when experiencing difficulties ...
Lei Yuan, Pan Zhao, Jiandong Zhang, Xiaoxiong Xu, Mingliang Jin, Ziyu Fang, Chunya Wang, Meina Li   +7 more
doaj   +1 more source

Focus on Translational Research

Molecular Plant-Microbe Interactions, 2014
Readers of this journal are well aware how far our field has progressed towards mechanistic understanding of pathogenesis and immunity. Almost concurrently, this new fundamental knowledge is being translated into new tools for reducing disease losses in ...
John M. McDowell, John Carr, Matteo Lorito   +2 more
doaj   +1 more source