Results 41 to 50 of about 51,482,470 (263)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Towards a translational medical research ecosystem [PDF]

, 2011
In this paper we introduce a novel design for a translational medical research ecosystem. Translational medical research is an emerging field of work, which aims to bridge the gap between basic medical science research and clinical research/patient care.
Smith, Matthew, Lewis, Andrew, Griffiths, L, Matthew Smith, Mertins, Susanne, Harbach, Marian, Lyn Griffiths, Andrew Lewis, Griffiths, Lyn, Susanne Mertins, Mertins, S, Marian Harbach, Griffiths, Lyn R., Harbach, M, Smith, M, Lewis, A   +15 more
core   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Translational research in neuroanaesthesia

Journal of Neuroanaesthesiology and Critical Care, 2014
Translational research in anaesthesia provided great solutions to medicine, well beyond its scope, in the past. Exciting opportunities exist for neuroanaesthesiologists to conduct translational research not just in anaesthesia alone but in the wider ...
Ganne S. Umamaheswara Rao
doaj   +1 more source

Translational research in thoracic surgery-the National Taiwan University Hospital experience

, 2017
Thoracic surgeons should be more aware of the latest information about histopathological, genetic and epigenetic alterations that may influence treatment policy and patient outcome in the biomolecular era.
Lin, Mong-Wei;Yang, Pei-Wen;Lee, Jang-Ming, 李章銘   +1 more
core   +1 more source

APE-type non-LTR retrotransposons of multicellular organisms encode virus-like 2A oligopeptide sequences, which mediate translational recoding during protein synthesis [PDF]

, 2013
2A oligopeptide sequences (“2As”) mediate a cotranslational recoding event termed “ribosome skipping.” Previously we demonstrated the activity of 2As (and “2A-like sequences”) within a wide range of animal RNA virus genomes and non-long terminal repeat ...
Sukhodub, Andriy, Ryan, MD, De Felipe, Pablo, Ruan, L, Odon, Valerie Marie Nathalie, de Felipe, P, Sukhodub, A, Luke, Garry Alec, Ruan, Lin, Escuin-Ordinas, H, Roulston, Claire, Odon, V, Ryan, Martin Denis, Brown, JD, Roulston, C, Brown, Jeremy, Luke, GA, Escuin, Helena   +17 more
core   +1 more source

The translational science promotion and research capacity (T-SPARC) framework: Developing institutional capacity for translational science

Journal of Clinical and Translational Science
Recent years have seen increasing focus, including by the National Institutes for Health (NIH), on developing the field of translational science (TS). TS focuses on improving the process of translational research (TR), including generating knowledge that
Jessica Sperling, Stella Quenstedt, Kristine Glauber, Perusi B. Muhigaba, Eman Ghanem, Tarun Saxena, Vonda Rodriguez, Cinthia Sanchez, F. Joseph McClernon   +8 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Use of Patient Stories as a Knowledge Translation Strategy to Facilitate the Sustainability of Evidence-Based Interventions (EBIs) in Healthcare

Patient Experience Journal
Background: Patient stories are real-life experiences told from a patient’s or their family’s perspective. In the past, patient stories have served many purposes in healthcare, such as spreading knowledge, educating providers, or conveying the patient ...
Rachel Flynn, Lauren Dobson, Ella Milne, Alyson Campbell, Kelly Mrklas, Tracy Wasylak, Shannon D. Scott   +6 more
doaj   +1 more source