Results 51 to 60 of about 1,176,635 (293)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Improving basic and translational science by accounting for litter-to-litter variation in animal models [PDF]

, 2013
Background: Animals from the same litter are often more alike compared with animals from different litters. This litter-to-litter variation, or "litter effects", can influence the results in addition to the experimental factors of interest.
Essioux, Laurent, Lazic, Stanley E.
core   +2 more sources

Adapting the Ideas of Translational Science for Translational Family Science [PDF]

Family Relations, 2017
Family science has been doing translational science since before it came into vogue. Nevertheless, the field has been subjected to the same forces in the broader academy that have created a widening chasm between discovery and practice. Thus, the primary objective of this article is to translate the principles, concepts, and models of translational ...
Joseph G, Grzywacz, Jeffrey W, Allen
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Evaluation as a translational resource: Bridging social sciences with clinical and translational sciences to advance university, health system, and community initiatives

Journal of Clinical and Translational Science
Evaluation supports the translation of knowledge into practice by systematically assessing what works, for whom, and under what conditions. It generates evidence to guide improvements, inform decision-making, and identify how programs, research studies ...
Jessica Sperling, Perusi B. Muhigaba, Stella Quenstedt, Noelle Wyman Roth, Adrian Brown, F. Joseph McClernon   +5 more
doaj   +1 more source

Ready, Set, Network! Research Speed Networking for Clinicians, Scientists and Engineers [PDF]

, 2016
Objectives: A 2013 Institute of Medicine report urged researchers to “engage in additional substantive and productive collaborations” to address important clinical/translational science questions. To encourage team science among our researchers, Tompkins-
Dillon, Pamela M, Gau, Karen H
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Development of TRACER: A Translational Research Accomplishments Cataloguer for Clinical and Translational Science Award hub activity tracking, evaluation, and decision-making

Journal of Clinical and Translational Science
Organizations supporting translational research and translational science, including Clinical and Translational Science Award (CTSA) hubs, provide a diverse and often changing array of resources, support, and services to a myriad of researchers and ...
Jessica Sperling, Stella Quenstedt, Anthony Leiro, Perusi B. Muhigaba, F. Joseph McClernon   +4 more
doaj   +1 more source

Subanesthetic ketamine treatment promotes abnormal interactions between neural subsystems and alters the properties of functional brain networks [PDF]

, 2014
Acute treatment with subanesthetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely utilized as a translational model for schizophrenia. However, how acute NMDA receptor blockade impacts on brain functioning at a
A Bifone, A Marsman, A Nikiforuk, A Stuchlik, A Verma, AC Lahti, AK Malhotra, AS Meyer-Lindenberg, B Moghaddam, BM Roberts, Brian J Morris, C Chih-Liang, C Corradi-Dell'Acqua, C De la Fuente-Sandoval, C Mirjana, Carsten M. Klingner, CJA Morgan, DC D’Souza, Desmond J Higham, DS Bassett, FR Sharp, FX Vollenweider, FX Vollenweider, G Paxinos, GD Honey, GE Duncan, H Metzer, J Cosgrove, J McCulloch, JA Saunders, JD Jentsch, JH Krystal, JH Krystal, JJ Kim, JM McNally, Judith A Pratt, JW Langsjo, JW Moore, K Hill, K Skoblenick, L Deserno, LJ Steward, M Amargos-Bosch, M Hauser, M Irifune, M Niesters, Martin McDonald, ME Jackson, ME Lynall, N Dawson, N Dawson, N Dawson, N Dawson, N Lindefors, N Pitsikas, ND Woodward, Neil Dawson, NR Driesen, R Galci, R Schlösser, RC Welsh, S Benetti, S Marenco, S Micheloyannis, S Miyamoto, SA Spence, SM Cochran, SP Kulikova, SY Yang, T Kos, T Kubota, Tatsunobu Natsubori, VP Bakshi, X Xiao, Y Li, Y Liu, Y Zhang, Y Zhou   +77 more
core   +1 more source

Translating science into business [PDF]

Nature, 2007
The right kind of postgraduate training could help you to realize biotech's potential as well as your own.
openaire   +2 more sources