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Molecular Biology and Evolution, 2013 Synonymous codon usage patterns are shaped by a balance between mutation, drift, and natural selection. To date, detection of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population ...
Aoife Doherty +2 more
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Compounds for selective translational inhibition
Current Opinion in Chemical Biology, 2022Since many human diseases are caused by the unwelcome production of harmful proteins, compounds that selectively suppress protein synthesis should provide a unique path for drug development, expanding the druggable proteome. Although surveying the RNA/amino acid contexts that are preferentially affected by translation inhibitors has presented an ...
Yuichi Shichino, Shintaro Iwasaki
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Translational selection shapes codon usage in the GC-rich genome of Chlamydomonas reinhardtii
FEBS Letters, 2001 In unicellular species codon usage is determined by mutational biases and natural selection. Among prokaryotes, the influence of these factors is different if the genome is skewed towards AT or GC, since in AT-rich organisms translational selection is ...
Hugo Naya +2 more
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Selective translation of mRNAs at synapses
Current Opinion in Neurobiology, 2002Synaptic efficacy, a phenomenon that may underlie long-term memory storage, is controlled in part by the regulated translation of mRNAs stored in dendrites. The molecular basis by which specific mRNAs are selected for translation is beginning to emerge and appears to involve at least one mechanism that helps program early metazoan development.
Joel D, Richter, Lori J, Lorenz
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Translational selection and molecular evolution
Current Opinion in Genetics & Development, 1998An interplay among experimental studies of protein synthesis, evolutionary theory, and comparisons of DNA sequence data has shed light on the roles of natural selection and genetic drift in 'silent' DNA evolution.
H, Akashi, A, Eyre-Walker
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Gene, 2000 Natural selection appears to discriminate among synonymous codons to enhance translational efficiency in a wide range of prokaryotes and eukaryotes. Codon bias is strongly related to gene expression levels in these species.
Hiroshi Akashi
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Iterative Feature Selection of Translation Texts for Translator Identification
2012Translation is an activity to transform linguistic information to another language. Translation product is a written text in a target-language (TL), which represents the result of a translation process, has been described by a comparison with the respective source-language (SL) text.
Kuo-Ming Tang (Fayuan) +3 more
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