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Compounds for selective translational inhibition
Current Opinion in Chemical Biology, 2022Since many human diseases are caused by the unwelcome production of harmful proteins, compounds that selectively suppress protein synthesis should provide a unique path for drug development, expanding the druggable proteome. Although surveying the RNA/amino acid contexts that are preferentially affected by translation inhibitors has presented an ...
Yuichi Shichino, Shintaro Iwasaki
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Selective translation of mRNAs at synapses
Current Opinion in Neurobiology, 2002Synaptic efficacy, a phenomenon that may underlie long-term memory storage, is controlled in part by the regulated translation of mRNAs stored in dendrites. The molecular basis by which specific mRNAs are selected for translation is beginning to emerge and appears to involve at least one mechanism that helps program early metazoan development.
Joel D, Richter, Lori J, Lorenz
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