Results 91 to 100 of about 277,260 (289)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Currently & Emotion: Translations
, 2016 Currently & Emotion presents a varied and carefully curated selection of works which foreground the translator, and, by showcasing a broad range of approaches, seek to challenge dominant perceptions of translation as an uncomplicated literary service
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Iranian Rehabilitation Journal, 2019 Objectives: The elderly residents of nursing homes experience falling at least once a year. The fear of falling influences the quality of life and causes limitations in their daily living activities.
Mahsa Fadavi-Ghaffari +4 more
doaj
Belitung Nursing JournalBackground: Acculturation provides a framework for exploring the health behaviors of ethnic minority or cultural groups. Research on the acculturation level and patterns of Myanmar migrants is crucial since there is ample evidence that acculturation ...
Htet Shwe Wah Oo +2 more
doaj +1 more source
Translation as a Process and Translation as a Product in Teaching Translation
Sintagma, 2003 L'ensenyament de la traducció s'ha utilitzat tradicionalment en algunes titulacions de filologia com a eina d'aprenentatge d'habilitats de la llengua. Aquesta circumstància, però, no ha d'estar renyida amb la producció d'una traducció acceptable. En aquest article es pretén analitzar si pot aconseguir-se aquest objectiu mitjançant la incorporació d ...
openaire +3 more sources
, 2023 Abstract Chapter 2 uses a multilingual corpus of English, Japanese and Chinese translations to survey general tendencies and experimental approaches. My focus on extreme cases reclaims the work of the translator as authorship. The analysis starts out with an account of Werther’s own translations from Ossian.
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Some linguistic remarks regarding Romanian Viking Studies [PDF]
Revista Română pentru Studii Baltice şi Nordice, 2013 In Romania there is no academic program dedicated entirely to the study of the Viking period in Scandinavia and Europe, but Romanian historiography can still boast with a decent number of monographs, translations and studies relating to early medieval ...
Costel Coroban
doaj