Results 101 to 110 of about 277,260 (289)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

'Foreign' books for English readers : published translations of navigation manuals and their audience in the English Renaissance, 1500-1640 [PDF]

open access: yes
Although there has been an increasing interest in the study of Renaissance translations and the early world of print, the history of navigation and exploration has not been the subject of any such in-depth bibliographical research.
Schepper, Susanna L. B. de
core  

Translations

open access: yes, 2015
Translations of study materials from English to Turkish (TR) and back translations from Turkish to English (TR-EN)
dilan tanis   +5 more
core   +2 more sources

Economics of literary translation : A simple theory and evidence [PDF]

open access: yes
Books are an important factor of cultural transmission, but need, in most cases, to be translated. According to some authors, this may lead to a form of cultural domination, in particular of English, on other languages.
WEBER, Shlomo   +2 more
core   +2 more sources

"De arauigo en lenguaie castellano": Politica linguistica e traduzione secondo Alfonso X

open access: yesLingue e Linguaggi, 2015
– After Alfonso X’s accession to the throne in mid-13th-century Spain, the translating activity of scientific texts from Arabic changed route: Castilian, instead of Latin, became the language of science.
Ruggiero Pergola
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Bible translations in Malo dialect

open access: yes, 1978
Includes the Lord's Prayer; Liturgy of Melanesia; Mealue Materials; Tapes: recordings of Ayiwo-English Index - Tape 1: 1-57; 58-103. Corrections only. -- Tape 2: 104-152 and story: Nye Kwee Go Sime Lato Kiyagouaka; Translation of Luke 1 and other bible ...
Wurm, Stephen Adolphe
core  

„Vămile văzduhului” de la mitologie folclorică la segment narativ [PDF]

open access: yesRevista de Istorie și Teorie Literară, 2013
The present paper studies the manner in which the parable (narration) of the customs of heaven is used as a narrative insertion in the context of a sermon about archangels.
Luisa Valmarin
doaj  

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