Results 111 to 120 of about 122,774 (265)
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
A Stylometric Analog of the Fermi-Pasta-Ulam-Tsingou Problem: Combination of Human Bias and Long-Range Correlation Creates a Sort of Soliton. [PDF]
Hayata K.
europepmc +1 more source
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Semantic convergence in culturally loaded text translation by Large Language Models: a cross-model empirical analysis of English translations of <i>The Four Books</i>. [PDF]
Wan Q, Yu Q.
europepmc +1 more source
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Comparing Large Language Models and Traditional Machine Translation Tools for Translating Medical Consultation Summaries: Quantitative Pilot Feasibility Study. [PDF]
Li A, Zhou W, Hoda R, Bain C, Poon P.
europepmc +1 more source
C. Michael Valentine +2 more
openaire +1 more source

