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The translatome of neuronal cell bodies, dendrites, and axons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Proteins are the key drivers of neuronal synaptic function. The regulation of gene expression is important for the formation and modification of synapses throughout the lifespan. The complexity of dendrites and axons imposes unique challenges for protein supply at remote locations.
Caspar Glock +2 more
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Studying the Translatome with Polysome Profiling
Methods in Molecular Biology, 2016Polysome fractionation by sucrose density gradient centrifugation followed by analysis of RNA and protein is a technique that allows to understand the changes in translation of individual mRNAs as well as genome-wide effects on the translatome. Here, we describe the polysome profiling technique and RNA as well as protein isolation procedures from ...
Angelika Modelska, Paola Zuccotti
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A hidden translatome in tumors—the coding lncRNAs
Science China Life Sciences, 2023Long noncoding RNAs (lncRNAs) have been extensively identified in eukaryotic genomes and have been shown to play critical roles in the development of multiple cancers. Through the application and development of ribosome analysis and sequencing technologies, advanced studies have discovered the translation of lncRNAs.
Jinsong, Wang +3 more
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Regulation of the Translatome in Cardiac Remodeling
The FASEB Journal, 2022Gene expression is determined by both transcriptional as well as multiple layers of post‐transcriptional controls, including protein translation. One of the molecular hallmark observed in diseased hearts is augmented protein synthesis and marked reprogramming of translatome (defined as ribosomal loaded mRNAs).
Yibin Wang +2 more
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The Translatome Map: RNC-Seq vs. Ribo-Seq for Profiling of HBE, A549, and MCF-7 Cell Lines
International Journal of Molecular SciencesGene expression is a tightly regulated process that involves multiple layers of control, including transcriptional, post-transcriptional, and translational regulation.
Ekaterina Ilgisonis +2 more
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Translational control of immune responses: from transcripts to translatomes
Nature Immunology, 2014Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent ...
Piccirillo, Ciriaco A. +4 more
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Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database
Cell Reports, 2022Stephanie Simard +2 more
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Efficient Detection of the Alternative Spliced Human Proteome Using Translatome Sequencing
Frontiers in Molecular Biosciences, 2022Dehua Li, Gong Zhang, Qing-Yu He
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