Results 181 to 190 of about 5,654 (195)

Innervation and cargo-specific axonal transport impairments in FUS-ALS mice with gain and loss of function

Simkin RL, Tosolini AP, Mikheenko A, Ule AM, Jin W, Kalmar B, Ahmed M, Lang Q, Lirot F, McLaughlin MF, Price G, Villarroel-Campos D, Greensmith L, Sleigh JN, Cunningham TJ, Schiavo G, Fisher EMC, Fratta P, Birsa N.   +18 more
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A hidden translatome in tumors—the coding lncRNAs

Science China Life Sciences, 2023
Long noncoding RNAs (lncRNAs) have been extensively identified in eukaryotic genomes and have been shown to play critical roles in the development of multiple cancers. Through the application and development of ribosome analysis and sequencing technologies, advanced studies have discovered the translation of lncRNAs.
Jinsong, Wang, Wenna, Wang, Fei, Ma, Haili, Qian   +3 more
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Spatially resolved single-cell translatomics at molecular resolution

Science, 2023
The precise control of messenger RNA (mRNA) translation is a crucial step in posttranscriptional gene regulation of cellular physiology. However, it remains a challenge to systematically study mRNA translation at the transcriptomic scale with spatial and single-cell resolution. Here, we report the development of ribosome-bound mRNA mapping (RIBOmap), a
Hu Zeng, Jiahao Huang, Jingyi Ren, Connie Kangni Wang, Zefang Tang, Haowen Zhou, Yiming Zhou, Hailing Shi, Abhishek Aditham, Xin Sui, Hongyu Chen, Jennifer A. Lo, Xiao Wang   +12 more
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Affinity purification of ribosomes to access the translatome

Methods, 2009
We describe ribosome affinity purification (RAP), a method that allows rapid purification of ribosomes and associated messages from the yeast Saccharomyces cerevisiae. The method relies on the expression of protein A tagged versions of the ribosomal protein Rpl16, which is used to efficiently recover endogenously formed ribosomes and polysomes from ...
Halbeisen, RE, Scherrer, T, Gerber, AP
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Studying the Translatome with Polysome Profiling

2016
Polysome fractionation by sucrose density gradient centrifugation followed by analysis of RNA and protein is a technique that allows to understand the changes in translation of individual mRNAs as well as genome-wide effects on the translatome. Here, we describe the polysome profiling technique and RNA as well as protein isolation procedures from ...
Paola, Zuccotti, Angelika, Modelska
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Regulation of the Translatome in Cardiac Remodeling

The FASEB Journal, 2022
Gene expression is determined by both transcriptional as well as multiple layers of post‐transcriptional controls, including protein translation. One of the molecular hallmark observed in diseased hearts is augmented protein synthesis and marked reprogramming of translatome (defined as ribosomal loaded mRNAs).
Yibin Wang, He (Iris) Wang, Frank YiFan Wang   +2 more
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Translational control of immune responses: from transcripts to translatomes

Nature Immunology, 2014
Selective translational control of gene expression is emerging as a principal mechanism for the regulation of protein abundance that determines a variety of functions in both the adaptive immune system and the innate immune system. The translation-initiation factor eIF4E acts as a node for such regulation, but non-eIF4E mechanisms are also prevalent ...
Piccirillo, Ciriaco A., Bjur, Eva, Topisirovic, Ivan, Sonenberg, Nahum, Larsson, Ola   +4 more
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Dorsal Striatum Parvalbumin interneurons translatome unveiled

AbstractParvalbumin (PV) interneurons in the dorsal striatum (DS) are fast-spiking GABAergic cells critical for feedforward inhibition and synaptic integration within basal ganglia circuits. Despite their well-characterized electrophysiological roles, their molecular identity remains incompletely defined.
Claire Naon, Laia Castell, Steeve Thirard, Maria Moreno, Stéphanie Rialle, Eva Goetz, Eloi Casals, Angelina Rogliardo, Marta Gut, Anna Esteve-Codina, Albert Quintana, Federica Bertaso, Emmanuel Valjent, Laura Cutando   +13 more
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Translatome Shifting Enhances Efficacy of Cellular Immunotherapies

The immune system makes decisions in response to complex combinations of microbial or adjuvant inputs. However, the combinatorial effects of multi-input stimulations on the protein life cycle of immune cells remain largely unknown. Here, we systematically measured changes in global protein synthesis induced by an adjuvant triplet combination in primary
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Review for "The translatome of glioblastoma"

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