Results 101 to 110 of about 301,236 (308)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Tratamento com células-tronco mesenquimais para aplasia medular felina

open access: yesPubvet
O tratamento com células-tronco mesenquimais (CTM) é uma das terapias da medicina regenerativa. Administrado por via intraóssea, acessando a medula óssea, representa uma promissora ferramenta de tratamento para doenças degenerativas ou não, como a ...
Rafaela Cassaniga   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

TRANSLATOR APPLICATIONS MESSENGER JAVA BASED AND GOOGLE TRANSLATE API [PDF]

open access: yes, 2013
The purpose of this research is to produce a messenger applications such as Messenger Translator Applications. Then test the feasibility of the application as an application that makes it easy to translate language or translator in chat communication ...
Novita, Anindita
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Ideology of Translation Concept Approach on Determining a Decision by the Translator [PDF]

open access: yes, 2017
The current study is aimed at exploring the ideology of the translation concept approach to determining a decision by the translator. The translator has faced the issues on how the way to determining a perspective view to adapt to domestication or ...
Amstrong, M. G. (Mike)   +2 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Methods of translating war-related collocations: A case study of Yemeni undergraduates

open access: yesمجلة الدراسات الاجتماعية
The present research project aims to explore translation methods adopted by Yemeni undergraduates when translating war-related collocations from English to Arabic and vice versa.
Mohammed Hasan ALFattah   +1 more
doaj   +1 more source

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