Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The expert's cadence, the novice's rush: A multi-level analysis of cognitive rhythm in translation production under pressure. [PDF]
PLoS OneWeng Y.
europepmc +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Structured Schemas for Provenance-Rich, LLM-Assisted QSP Model Calibration. [PDF]
CPT Pharmacometrics Syst PharmacolEliason J, Popel AS.
europepmc +1 more source
Evaluation of Nurses' Intent to Leave: Italian Translation, Cultural Adaptation, and Initial Psychometric Assessment of the Anticipated Turnover Scale. [PDF]
Nurs OpenCignola S, Bembich S, Sanson G.
europepmc +1 more source
Contemporary Chinese newspaper discourse on translation: A mixed-methods approach to the People's Daily (1949-2023). [PDF]
PLoS OneShi X, Huang L.
europepmc +1 more source
Pharmacist-led educational intervention to improve knowledge, medication adherence, and asthma control among asthma patients at Ayder Comprehensive Specialized Hospital: A protocol for randomized controlled trial. [PDF]
PLoS OneTekele MD +5 more
europepmc +1 more source
Positive mood enhances accessibility of unrelated concepts in the first language but not in the foreign language. [PDF]
PLoS OneŻukowski P, Naranowicz M.
europepmc +1 more source
Translation and cross-cultural adaptation of the parental version of Type 1 Diabetes and Life (T1DAL): a US patient-reported outcome measurement into Danish following ISPOR guidelines. [PDF]
BMJ OpenLind N, DeCosta P, Svensson J.
europepmc +1 more source