Results 161 to 170 of about 56,063 (262)

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Using Design Thinking to Develop a Tool for Strengthening Nurses' Cultural Competence: Lessons Learned. [PDF]

J Transcult Nurs
Duran-Kiraç G, Uittenbroek R, van Hout H, Broese van Groenou MI.   +3 more
europepmc   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Understanding the psychological pathways to translation technology competence: emotional intelligence, self-esteem, and innovation capability among EFL students. [PDF]

BMC Psychol
Zhao J, Li X, Wei J, Long X, Gao Z.
europepmc   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Color as physical/conceptual attribute: Color word translation by Chinese postgraduate students. [PDF]

PLoS One
Wang H, Lv G, Tian X.
europepmc   +1 more source

Norms and the determination of translation: a theoretical framework [PDF]

, 1996
Hermans, T
core  

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

A Protocol for the International Translation and Validation of the Postpartum Specific Anxiety Scale for Preterm Birth [PSAS-PTB] and Neonatal Intensive Care Unit [PSAS-NICU] Contexts. [PDF]

Int J Methods Psychiatr Res
Worrall S, Fallon V, Christiansen P, Khalil A, Spencer R, Fresno A, Wormald F, Nakić Radoš S, Katušić A, Kostović M, Azim Aburas K, Moussa S, Wendland J, Crivano GM, Yahiaoui A, Stenzel N, Payne E, Wittkowski A, Mirghafourvand M, Mashayekh-Amiri S, Yatziv T, Gueron-Sela N, Bramante A, Ionio C, Ciuffo G, Jarašiūnaitė-Fedosejeva G, Gibė E, Stankevičienė V, SaadAdeen S, Moreira H, Caiado B, Rebega OL, Aparicio-García ME, Costas-Ramón N, Cárdaba-García RM, Kariyawasam A, Maduwanthi M, Thilakarathne R, Silverio SA, Global Consortium for Perinatal Psychometrics.   +39 more
europepmc   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source