Results 81 to 90 of about 13,063 (261)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Good Translator. Emic-cum-etic perspectives on translator competence and expertise

JoSTrans: The Journal of Specialised Translation
Translator competence and expertise has been the object of much scholarly reflection and research, but studies that address practitioners’ perspectives on the topic remain limited.
Helle Vrønning Dam, Anja Krogsgaard Vesterager, Karen Korning Zethsen   +2 more
doaj   +1 more source

Commenting on translation: implications for translator training

JoSTrans: The Journal of Specialised Translation, 2011
As translation research moves towards investigating translation processes and not just products, researchers have begun to examine the effects of those processes on the quality of target texts.
Gary Massey, Maureen Ehrensberger-Dow
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An experimental study into the acquisition of cultural competence in translator training : research design and methodological issues [PDF]

, 2015
Despite the importance given to culture and cultural competence in Translation Studies, these concepts have only been developed at a theoretical level thus far.
Olalla-Soler, Christian
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Smart Learning Models of Certified Legal Translators and Interpreters in China

Comparative Legilinguistics, 2018
Legal translation has played an important part in the contact between different people and countries in the history, and it is playing an even more significant role in the increasingly globalized world nowadays.
Ming XU
doaj   +1 more source

A Survey of the Yemeni Translation Market Needs

مجلة الدراسات الاجتماعية, 2019
Academic programs have changed to become learner-centered. As such, programs are based on the competences that learners should acquire. One major source for these competences is the market.
Eman Alshargabi, Mohammed Abdu Al-Mekhlafi   +1 more
doaj   +1 more source