Results 121 to 130 of about 161,190 (310)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Revisiting Reflection: AI-Driven Transformation of Translation Reflection
Research in LanguageThis conceptual article extends Chesterman’s 1997 stages of translation by three additional stages – problem solving, processing, and co-evolving – and redefines translation through reflective practice.
Carmen Heine
doaj +1 more source
NATURALNESS IN TRANSLATION OF ENGLISH NOVEL INTO INDONESIAN [PDF]
, 2015 Naturalness in translation is a very important point in relation to translation product quality. This paper is a research-based article on the translation of English-novel into Indonesian.
Baharuddin, Baharuddin
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Translational Educational Research [PDF]
Chest, 2012 William C. McGaghie +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Revista de Istorie și Teorie Literară, 2008 The last inteview (January 2008, Radio Trinitas) with professor Dan Sluşanschi (1943–2008), a remarkable translator from Medieval Greek and Latin revealed some unknown aspects of translating. Dan Sluşanschi talked about the beauty of Cantemir’s language (
Dan Sluşanschi, Lucia Toader
doaj
The Importance of Culture in Evaluation: A Practical Guide for Evaluators [PDF]
, 2007 Offers guidance on designing and conducting a cross-culturally competent program evaluation that takes into account how culture, social identity or group membership, and privilege and power affect responses.
Kien Lee
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Active, strategic reading for translation trainees: Foundations for transactional methods
Translation and Interpreting : the International Journal of Translation and Interpreting Research, 2012 The often-neglected issue of reading—a skill that is inextricable from translation--affects virtually every aspect of a translator trainee’s profile, from resourcing skills to background knowledge to linguistic competence itself.
Kelly Washbourne
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