Results 91 to 100 of about 3,184,218 (349)

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Detection of a balanced translocation carrier through trophectoderm biopsy analysis: a case report

Molecular Cytogenetics, 2019
Background Balanced translocation carriers are burdened with fertility issues due to improper chromosome segregation in gametes, resulting in either implantation failure, miscarriage or birth of a child with chromosomal disorders. At the same time, these
Olga Tšuiko, Tuuli Dmitrijeva, Katrin Kask, Pille Tammur, Neeme Tõnisson, Andres Salumets, Tatjana Jatsenko   +6 more
doaj   +1 more source

Translocation and Aquaculture Impact on Genetic Diversity and Composition of Wild Self-Sustainable Ostrea edulis Populations in the Adriatic Sea

Frontiers in Marine Science, 2020
The European flat oyster, Ostrea edulis, is a keystone species suffering major population declines due to overfishing, habitat loss and parasite diseases.
Tanja Šegvić-Bubić, Iva Žužul, Igor Talijančić, Nika Ugrin, Ivana Lepen Pleić, Luka Žuvić, Nika Stagličić, Leon Grubišić   +7 more
doaj   +1 more source

Conserving the genetic diversity of condemned populations: Optimizing collections and translocation

Evolutionary Applications, 2021
We consider approaches for conserving genetic diversity from plant populations whose destruction is imminent. We do this using SNP genotype data from two endangered species, Pimelea spicata and Eucalyptus sp. Cattai. For both species, we genotyped plants
Jason G. Bragg, Jia‐Yee S. Yap, Trevor Wilson, Enhua Lee, Maurizio Rossetto   +4 more
doaj   +1 more source

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]

, 2017
The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core   +1 more source

Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations.

Blood, 2007
Follicular lymphoma (FL) is genetically characterized by the presence of the t(14;18)(q32;q21) chromosomal translocation in approximately 90% of cases.
E. Leich, I. Salaverria, S. Beá, A. Zettl, George W. Wright, V. Moreno, R. Gascoyne, W. Chan, R. Braziel, L. Rimsza, D. Weisenburger, J. Delabie, E. Jaffe, A. Lister, J. Fitzgibbon, L. Staudt, E. Hartmann, H. Mueller-Hermelink, E. Campo, G. Ott, A. Rosenwald   +20 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The genetic legacy of the first successful reintroduction of a mammal to Britain: Founder events and attempted genetic rescue in Scotland's beaver population

Evolutionary Applications
Conservation translocations often inherently involve a risk of genetic diversity loss, and thus loss of adaptive potential, but this risk is rarely quantified or monitored through time.
Helen R. Taylor, Jean‐Marc Costanzi, Kara L. Dicks, Helen V. Senn, Sarah Robinson, Gill Dowse, Alex D. Ball   +6 more
doaj   +1 more source

Impact of template backbone heterogeneity on RNA polymerase II transcription. [PDF]

, 2014
Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution.
Chong, Jenny, Huang, Xuhui, Wang, Dong, Wang, Wei, Xu, Liang, Zhang, Lu   +5 more
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source