Results 71 to 80 of about 3,668,773 (354)

Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma [PDF]

, 2010
We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript.
Jakovljević, Gordana, Kardum-Skelin, Ika, Krušlin, Božo, Mrsić-Davidović, Sanja, Nakić, Melita, Rogošić, Srđan, Zadro, Renata   +6 more
core   +1 more source

Características genéticas da leucemia promielocítica aguda de novo Genetics characteristics of de novo acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2009
Geneticamente, a leucemia promielocítica aguda (LPA) caracteriza-se por alterações cromossômicas estruturais recorrentes, na grande maioria das vezes translocações, envolvendo sempre o lócus gênico para o receptor alfa do ácido retinoico (RARα ...
Aline M. Leal, Cristina A. Kumeda, Elvira D. R. P. Velloso   +2 more
doaj  

Correlation Between C-MYC, BCL-2, and BCL-6 Protein Expression and Gene Translocation as Biomarkers in Diagnosis and Prognosis of Diffuse Large B-cell Lymphoma

Frontiers in Pharmacology, 2019
This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities.
YunXiang Zhang, Hui Wang, Cuiai Ren, Hai Yu, Wenjia Fang, Na Zhang, Sumei Gao, Qian Hou   +7 more
doaj   +1 more source

Clinical effect of chromosome balanced translocation study of the effect on genomic stability

生物医学转化, 2022
Objective To explore the effect of chromosome balanced translocation on genomic stability. Methods Abnormal embryos from patients with preimplantation genetic testing for structural rearrangements (PGTSR) indication between January 2019 and December 2020
Gao Ming, Wang Lijuan, Zou Yang, Xie Hongqiang, Liu Xiaowei, Huang Sexin, Gao Yuan   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Reassessment of the evolution of wheat chromosomes 4A, 5A, and 7B. [PDF]

, 2018
Key messageComparison of genome sequences of wild emmer wheat and Aegilops tauschii suggests a novel scenario of the evolution of rearranged wheat chromosomes 4A, 5A, and 7B.
Deal, Karin R, Devos, Katrien M, Distelfeld, Assaf, Dvorak, Jan, Gill, Bikram S, Gu, Yong Q, Jorgensen, Chad M, Luo, Ming-Cheng, McGuire, Patrick E, Qi, Peng, Wang, Le, Zhu, Tingting   +11 more
core  

Wildlife translocation: the conservation implications of pathogen exposure and genetic heterozygosity

BMC Ecology, 2011
BackgroundA key challenge for conservation biologists is to determine the most appropriate demographic and genetic management strategies for wildlife populations threatened by disease.
Walter M. Boyce, Mara E. Weisenberger, M. C. T. Penedo, Christine K. Johnson   +3 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. [PDF]

, 2016
Synovial sarcomas are aggressive soft-tissue malignancies that express chromosomal translocation-generated fusion genes, SS18-SSX1 or SS18-SSX2 in most cases.
Barrott, JJ, Cairns, BR, Capecchi, MR, Ding, L, Haldar, M, Jin, H, Jones, KB, Langer, EM, Monument, MJ, Mosbruger, TL, Randall, RL, Wilson, RK, Xie, M, Zhu, J-F   +13 more
core  

Nanopore sequencing for detecting reciprocal translocation carrier status in preimplantation genetic testing

BMC Genomics, 2023
Background Balanced reciprocal translocation (BRT) is one of the most common chromosomal abnormalities that causes infertility, recurrent miscarriage, and birth defects.
Qiuping Xia, Shenglan Li, Taoli Ding, Zhen Liu, Jiaqi Liu, Yanping Li, Huimin Zhu, Zhongyuan Yao   +7 more
doaj   +1 more source