Results 91 to 100 of about 2,347,193 (305)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Journal of Human Reproductive Sciences, 2019 Robertsonian translocation is a subtype of balanced translocation involving two acrocentric chromosomes. Individuals who are carrier of this abnormality are at increased risk of infertility or bad obstetric history.
Paresh Singhal +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Use of selpercatinib in a patient with RET-mutated non-small cell lung cancer: case report
Сибирский онкологический журналBackground. The use of the modern targeted drugs in patients with non-small-cell lung cancer (NSCLC) with certain somatic alterations (genetic alterations in EGFR, ALK, ROS1, BRAF, RET genes, etc.) provides a significant increase in overall and disease ...
A. M. Kazakov +3 more
doaj +1 more source
Mechanisms of gene duplication and translocation and progress towards understanding their relative contributions to animal genome evolution [PDF]
, 2012 Duplication of genetic material is clearly a major route to genetic change, with consequences for both evolution and disease. A variety of forms and mechanisms of duplication are recognised, operating across the scales of a few base pairs upto entire ...
Mendivil Ramos, Olivia +1 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2015 A rare case of aniridia and balanced translocation (5:11)(p15.3;q22) arising in the same subject: et challenge for genetic counseling: The authors report on a case of isolated aniridia caused by haploinsufficiency of the PAX6 gene, which is located on ...
Maciel-Guerra, AT, Vulcan-Freitas, TM
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Translocation of Photosynthates in Deciduous Fruit Trees
, 2014 瞭解光合成產物之運移及分配，有助於生產者對作物栽培及生理特性之了解以作正確的管理。落葉果樹光合成產物運移之形式主要為蔗糖及糖醇，運移途徑由供源葉片器官裝載，然後沿韌皮部運移到積貯器官卸載，積貯器官之強度會隨著不同的生育階段而改變。落葉果樹每年出其生長刀比須依看貯藏光合成產物的再轉移，隨著葉片逐漸成熟輸出其光合成產物供應當年的生長與果實之發育，在果實收穫後則運移至貯藏器官。本文亦討論在不同生育階段供源與積貯間關係及其對光合成產物運移之影響。The understanding of ...
Chih-Sheng Chang, 張致盛
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