Results 61 to 70 of about 3,198,903 (351)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Cytomolecular identification of individual wheat-wheat chromosome arm associations in wheat-rye hybrids [PDF]

, 2013
Chromosome pairing in the meiotic metaphase I of wheatrye hybrids has been characterized by sequential genomic and fluorescent in situ hybridization allowing not only the discrimination of wheat and rye chromosomes, but also the identification of the
Badaeva ED, Badaeva ED, Bass HW, Bedbrook J, Berkman PJ, Cifuentes M, Cifuentes M, Cifuentes M, Colas I, Conley EJ, Contento A, Cuadrado A, Devos KM, Devos KM, Fedak G, Fernandez-Kalvin B, Ferrer E, Fominaya A, Gale MD, Gerlach WL, Gill BS, Hernandez P, Huang S, I. Molnár, Jauhar PP, Kamstra SA, Le HT, Logojan A, Lukaszewski AJ, M. Megyeri, M. Molnár-Láng, Martinez-Perez E, Martinez-Perez E, Miller TE, Molnár I, Molnár I, Molnár I, Molnár I, Molnár-Láng M, Molnár-Láng M, Mukai Y, Munkvold JD, Nagaki K, Naranjo T, Naranjo T, Naranjo T, Prieto P, Qi L, Riley R, Riley R, Sabot F, Schwarzacher T, Sepsi A, Sharp PJ, Szakács, Sánchez-Morán E, Tischner T   +56 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Correlation Between C-MYC, BCL-2, and BCL-6 Protein Expression and Gene Translocation as Biomarkers in Diagnosis and Prognosis of Diffuse Large B-cell Lymphoma

Frontiers in Pharmacology, 2019
This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities.
YunXiang Zhang, Hui Wang, Cuiai Ren, Hai Yu, Wenjia Fang, Na Zhang, Sumei Gao, Qian Hou   +7 more
doaj   +1 more source

Nanopore sequencing for detecting reciprocal translocation carrier status in preimplantation genetic testing

BMC Genomics, 2023
Background Balanced reciprocal translocation (BRT) is one of the most common chromosomal abnormalities that causes infertility, recurrent miscarriage, and birth defects.
Qiuping Xia, Shenglan Li, Taoli Ding, Zhen Liu, Jiaqi Liu, Yanping Li, Huimin Zhu, Zhongyuan Yao   +7 more
doaj   +1 more source

Reassessment of the evolution of wheat chromosomes 4A, 5A, and 7B. [PDF]

, 2018
Key messageComparison of genome sequences of wild emmer wheat and Aegilops tauschii suggests a novel scenario of the evolution of rearranged wheat chromosomes 4A, 5A, and 7B.
Deal, Karin R, Devos, Katrien M, Distelfeld, Assaf, Dvorak, Jan, Gill, Bikram S, Gu, Yong Q, Jorgensen, Chad M, Luo, Ming-Cheng, McGuire, Patrick E, Qi, Peng, Wang, Le, Zhu, Tingting   +11 more
core  

The 2NS Translocation from Aegilops ventricosa Confers Resistance to the Triticum Pathotype of Magnaporthe oryzae

Crop science, 2016
Wheat blast is a serious disease caused by the fungus Magnaporthe oryzae (Triticum pathotype) (MoT). The objective of this study was to determine the effect of the 2NS translocation from Aegilops ventricosa (Zhuk.) Chennav on wheat head and leaf blast ...
C. D. Cruz, G. L. Peterson, W. Bockus, P. Kankanala, J. Dubcovsky, K. W. Jordan, E. Akhunov, F. Chumley, F. D. Baldelomar, B. Valent   +9 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Características genéticas da leucemia promielocítica aguda de novo Genetics characteristics of de novo acute promyelocytic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2009
Geneticamente, a leucemia promielocítica aguda (LPA) caracteriza-se por alterações cromossômicas estruturais recorrentes, na grande maioria das vezes translocações, envolvendo sempre o lócus gênico para o receptor alfa do ácido retinoico (RARα ...
Aline M. Leal, Cristina A. Kumeda, Elvira D. R. P. Velloso   +2 more
doaj  

SYCP2 translocation-mediated dysregulation and frameshift variants cause human male infertility

bioRxiv, 2019
Infertility is one of the most common disorders for men of reproductive age. To identify novel genetic etiologies, we studied a male with severe oligozoospermia and 46, XY,t(20;22)(q13.3;q11.2).
Samantha L. P. Schilit, Shreya Menon, C. Friedrich, T. Kammin, E. Wilch, Carrie Hanscom, Sizun Jiang, S. Kliesch, M. Talkowski, F. Tüttelmann, A. MacQueen, C. Morton   +11 more
semanticscholar   +1 more source