Results 301 to 310 of about 1,195,157 (388)

Substrate‐Restricted Asymmetric Evolution of Solid‐State Nanopores

Advanced Theory and Simulations, EarlyView.
Standalone nanopores can either expand or shrink based on the nucleation mechanism. A substrate‐restricted asymmetric pore dynamics are uncovered ‐ top expansion and bottom shrinkage, with minimum aperture reduced and forming a conical geometry, driven by molecular migration along an energy potential gradient within nanopores.
Hongshuai Liu, Mingzhi Yu, Da Qu, Fengzhou Fang, Jufan Zhang   +4 more
wiley   +1 more source

Coordinated Residue Motions at the Enzyme-Substrate Interface Promote DNA Translocation in Polymerases. [PDF]

J Am Chem Soc
Visigalli A, Trizio E, Bonati L, Vidossich P, Parrinello M, De Vivo M.   +5 more
europepmc   +1 more source

Tryptophan Metabolite Indole‐3‐Aldehyde Induces AhR and c‐MYC Degradation to Promote Tumor Immunogenicity

Advanced Science, EarlyView.
Tryptophan metabolite Indole‐3‐aldehyde (I3A) downregulates cytosolic AhR and p‐ERK/c‐MYC proteins, together enhancing STAT3 phosphorylation and tumor immunogenicity. Overexpression of the Trp metabolic enzyme interleukin‐4‐induced gene‐1 (IL4I1) in tumor cells increases intracellular levels of I3A and enhances tumor immunogenicity.
Lei Cui, Zining Wang, Zixuan Guo, Hongxia Zhang, Yongxiang Liu, Huanling Zhang, Huan Jin, Feifei Xu, Xiaojuan Wang, Chunyuan Xie, Hui Guo, Tiantian Wang, Yanxun Lin, Qi Zhao, Penghui Zhou, Jing Tan, Jin‐Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +19 more
wiley   +1 more source

Genistein Enhances GLUT4 Expression and Translocation in the Gastrocnemius Muscle and Improves Systemic Glucose Metabolism in Ovariectomized Mice. [PDF]

Nutrients
Yang X, Dai K, Wang S.
europepmc   +1 more source

REVIEW: Translocation tactics: a framework to support the IUCN Guidelines for wildlife translocations and improve the quality of applied methods

, 2015
William G. Batson, I. Gordon, Donald B. Fletcher, A. Manning   +3 more
semanticscholar   +1 more source

Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor

Cell, 1996
B. Savage, E. Saldívar, Z. Ruggeri
semanticscholar   +1 more source

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Identification of a Novel Rice Chromosomal Translocation Line that Could Cause the Heterozygote Semi-Sterility and be Overcome by Genomic Duplication. [PDF]

Rice (N Y)
Deng R, You H, Ge Q, Wu J, Cheng Z, Zhu L, Yu H, Chen L, Shahid MQ, Lu Z, Liu X.   +10 more
europepmc   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Nidulin stimulates glucose uptake in myotubes through the IRS-AKT pathway and alters redox balance and intracellular calcium. [PDF]

Nat Prod Bioprospect
Chantarasakha K, Yangchum A, Isaka M, Tepaamorndech S.   +3 more
europepmc   +1 more source