Results 281 to 290 of about 1,020,829 (348)

SEC61: a potential therapeutic target in transplantation. [PDF]

Front Immunol
Saiz ML, Ruiz Bernet C, Lopez-Larrea C, Suarez-Alvarez B.   +3 more
europepmc   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Characterization of Acute Myeloid Leukemia With t(16;21) Translocation: Cytogenetic, Molecular, and Immunophenotypic Findings. [PDF]

World J Oncol
Bravo-Davila M, Espinoza-Rodrigez D, Orejon-Huarancca J, Zapata Dongo RJ.   +3 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

A dynamical anthrax toxin nanopore biosensor for high-fidelity single-peptide classification. [PDF]

PLoS Comput Biol
Colby JM, Krantz BA.
europepmc   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Origin of translocated animals is associated with time to settlement and post-translocation survival. [PDF]

Mov Ecol
Harju S, Cambrin S.
europepmc   +1 more source

Integrated Biochemical and Ultrastructural Responses of <i>Tanacetum vulgare</i> L. to Multi-Metal Stress. [PDF]

Plants (Basel)
Alliluev I, Chernikova N, Kazachkova V, Ahmad I, Fedorenko A, Popov V, Babenko A, Chaplygin V, Mandzhieva S, Minkina T.   +9 more
europepmc   +1 more source

Unique sex chromosome translocations and evolutionary strata in two Sylvioidea songbird families. [PDF]

BMC Genomics
Brown TJ, Ellerstrand SJ, Sigeman H, Melo M, Lundberg M, Hansson B.   +5 more
europepmc   +1 more source