Results 111 to 120 of about 659,557 (291)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
, 1990 The cytochrome c import pathway differs markedly from the general route taken by the majority of other imported proteins, which is characterized by the import involvement of namely, surface receptors, the general insertion protein (GIP), contact sites ...
Berkout +68 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cadmium-Induced Changes in the Accumulation of Sugars and the PsGolS Transcript in Pisum sativum L.
Applied SciencesCadmium (Cd) is a key stress factor that affects plant development. To examine the influence of Cd stress, we analysed the tissue localisation of polysaccharides (Periodic Acid Schiff reaction), qualitative and quantitative changes in soluble ...
Katarzyna Głowacka +5 more
doaj +1 more source
The conformations and basal conformational dynamics of translocation factor SecDF vary with translocon SecYEG interaction. [PDF]
J Biol Chem, 2022 Weaver DR, Amin DN, King GM.
europepmc +1 more source
Electrophoresis of a polyelectrolyte through a nanopore [PDF]
, 2006 A hydrodynamic model for determining the electrophoretic speed of a polyelectrolyte through a nanopore is presented. It is assumed that the speed is determined by a balance of electrical and viscous forces arising from within the pore and that classical ...
E. Lauga +8 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Nuclear factor translocation and acute anterior uveitis.
Molecular vision, 2011 To investigate the roles of activation of macrophages isolated from C3H/HeN and C3H/HeJ mice and stimulated by lipopolysaccharide (LPS), and toll-like receptor 4-mediated signal transduction in the development of acute anterior uveitis.Establish animal models with acute anterior uveitis by intraperitoneal injection of vibrio cholera endotoxin into C3H ...
Jing, Wang +6 more
openaire +1 more source
Physico‐chemical factors determining the phloem translocation of benzoic acids
Pesticide Science, 1993 AbstractA series of 14C‐labelled benzoic acids, chosen to permit assessment of the role of pKa and lipophilicity in determining movement in plants of these herbicide analogues, was synthesised and their phloem translocation investigated. Following application of substituted benzoic acids to castor bean, Ricinus communis L., by injection into the ...
Tench, A. J. +3 more
openaire +1 more source
, 2017 Understanding how different classes of molecules move across biological membranes is a prerequisite to predicting a solute's permeation rate, which is a critical factor in the fields of drug design and pharmacology.
Maibaum, Lutz, Pokhrel, Nihit
core +2 more sources