Results 31 to 40 of about 434,631 (260)

The transmembrane domain C of AMPA receptors is critically involved in receptor function and modulation

Frontiers in Molecular Neuroscience, 2010
Ionotropic glutamate receptors are major players in synaptic transmission and are critically involved in many cognitive events. Although receptors of different subfamilies serve different functions, they all show a conserved domain topology.
Jan Terhag, Jan Terhag, Jan Terhag, Kevin Gottschling, Michael Hollmann   +4 more
doaj   +1 more source

Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells?

Frontiers in Oncology, 2020
Cellular functions are regulated by extracellular signals such as hormones, neurotransmitters, matrix ligands, and other chemical or physical stimuli.
Camille Albrecht, Camille Albrecht, Aline Appert-Collin, Aline Appert-Collin, Dominique Bagnard, Dominique Bagnard, Sébastien Blaise, Sébastien Blaise, Béatrice Romier-Crouzet, Béatrice Romier-Crouzet, Roman G. Efremov, Roman G. Efremov, Hervé Sartelet, Hervé Sartelet, Laurent Duca, Laurent Duca, Pascal Maurice, Pascal Maurice, Amar Bennasroune, Amar Bennasroune   +19 more
doaj   +1 more source

Converting a transmembrane receptor to a soluble receptor: Recognition domain to effector domain signaling after excision of the transmembrane domain [PDF]

Proceedings of the National Academy of Sciences, 1997
The bacterial aspartate receptor was reconstructed to eliminate the transmembrane domain, thus connecting the recognition domain directly to the effector domain. The resulting soluble receptor folded correctly and was no longer an integral membrane protein.
K M, Ottemann, D E, Koshland
openaire   +2 more sources

CX3CL1, a chemokine finely tuned to adhesion: critical roles of the stalk glycosylation and the membrane domain

Biology Open, 2014
The multi-domain CX3CL1 transmembrane chemokine triggers leukocyte adherence without rolling and migration by presenting its chemokine domain (CD) to its receptor CX3CR1.
Mariano A. Ostuni, Julie Guellec, Patricia Hermand, Pauline Durand, Christophe Combadière, Frédéric Pincet, Philippe Deterre   +6 more
doaj   +1 more source

A Novel Form of Neuregulin 1 Type III Caused by N-Terminal Processing

Biomolecules, 2023
Nrg1 (Neuregulin 1) type III, a susceptible gene of schizophrenia, exhibits a critical role in the central nervous system and is essential at each stage of Schwann’s cell development.
Yukai Wang, Yu Zhang, Yingxing Wang, Hong Chen, Liangjing Pan, Xufeng Liao, Shunqi Wang   +6 more
doaj   +1 more source

Interactions between the transmembrane domains of CD39: identification of interacting residues by yeast selection.

ScienceOpen Research, 2014
Rat CD39, a membrane-bound ectonucleoside triphosphate diphosphohydrolase that hydrolyzes extracellular nucleoside tri- and diphosphates, is anchored to the membrane by two transmembrane domains at the two ends of the molecule.
Guido Guidotti, Sari Paavilainen
doaj   +1 more source

The roles of transmembrane domain helix-III during rhodopsin photoactivation. [PDF]

PLoS ONE, 2011
Rhodopsin, the prototypic member of G protein-coupled receptors (GPCRs), undergoes isomerization of 11-cis-retinal to all-trans-retinal upon photoactivation.
Wen-bin Ou, Tingfang Yi, Jong-Myoung Kim, H Gobind Khorana   +3 more
doaj   +1 more source

Membrane Topology of Subunit 8 Variant of Yeast Saccharomyces cerevisiae Mitochondrial ATP Synthase

Microbiology Indonesia, 2010
The yeast mitochondrial F1F0-ATP synthase is a multisubunit complex that contains at least 17 different subunits. Subunit 8 of yeast mitochondrial ATP synthase is a hydrophobic protein of 48 amino acids encoded by the mitochondrial ATP8 gene. There is no
I MADE ARTIKA
doaj   +1 more source

Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain

Frontiers in Molecular Biosciences, 2020
As a class C GPCR and regulator of synaptic activity, mGlu5 is an attractive drug target, potentially offering treatment for several neurologic and psychiatric disorders.
Isaias Lans, Isaias Lans, Óscar Díaz, Óscar Díaz, Óscar Díaz, James A. R. Dalton, James A. R. Dalton, James A. R. Dalton, Jesús Giraldo, Jesús Giraldo, Jesús Giraldo   +10 more
doaj   +1 more source

The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers

BMC Immunology, 2021
Background Invariant chain (CD74, Ii) is a multifunctional protein expressed in antigen presenting cells. It assists the ER exit of various cargos and serves as a receptor for the macrophage migration inhibitory factor.
Maryse Cloutier, Jean-Simon Fortin, Jacques Thibodeau   +2 more
doaj   +1 more source