Results 11 to 20 of about 434,631 (260)

Transmembrane Domain–Dependent Functional Oligomerization of Syndecans [PDF]

The Scientific World Journal, 2006
Cell surface adhesion receptors of the syndecan family initiate intracellular events through clustering of receptors. This crucial clustering occurs through receptor dimerization or oligomerization, which is mediated by receptor transmembrane domains ...
Jae Youn Yi, Innoc Han, Eok-Soo Oh
doaj   +3 more sources

Conformation of the synaptobrevin transmembrane domain [PDF]

Proceedings of the National Academy of Sciences, 2006
The synaptic vesicle protein synaptobrevin (also called VAMP, vesicle-associated membrane protein) forms part of the SNARE (soluble N -ethylmaleimide sensitive factor attachment protein receptor) complex, which is essential for vesicle fusion.
Mark, Bowen, Axel T, Brunger
openaire   +2 more sources

Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain [PDF]

International Journal of Molecular Sciences, 2021
Despite the known importance of the transmembrane domain (TMD) of syndecan receptors in cell adhesion and signaling, the molecular basis for syndecan TMD function remains unknown. Using in vivo invertebrate models, we found that mammalian syndecan-2 rescued both the guidance defects in C.
Jisun Hwang, Bohee Jang, Ayoung Kim, Yejin Lee, Joonha Lee, Chungho Kim, Jinmahn Kim, Kyeong Min Moon, Kyuhyung Kim, Ram Wagle, Young-Han Song, Eok-Soo Oh   +11 more
openaire   +3 more sources

Structural modeling of a novel membrane-bound globin-coupled sensor in Geobacter sulfurreducens

Computational and Structural Biotechnology Journal, 2021
Globin-coupled sensors (GCS) usually consist of three domains: a sensor/globin, a linker, and a transmitter domain. The globin domain (GD), activated by ligand binding and/or redox change, induces an intramolecular signal transduction resulting in a ...
Dietmar Hammerschmid, Francesca Germani, Salvador I. Drusin, Charline Fagnen, Claudio D. Schuster, David Hoogewijs, Marcelo A. Marti, Catherine Venien-Bryan, Luc Moens, Sabine Van Doorslaer, Frank Sobott, Sylvia Dewilde   +11 more
doaj   +1 more source

The role of palmitoylation and transmembrane domain in sorting of transmembrane adaptor proteins [PDF]

Journal of Cell Science, 2016
ABSTRACT Plasma membrane proteins synthesised at the endoplasmic reticulum are delivered to the cell surface via sorting pathways. Hydrophobic mismatch theory based on the length of the transmembrane domain (TMD) dominates discussion about determinants required for protein sorting to the plasma membrane.
Chum, T., Glatzová, D. (Daniela), Kvíčalová, Z. (Zuzana), Malínský, J. (Jan), Brdička, T. (Tomáš), Cebecauer, M. (Marek)   +5 more
openaire   +5 more sources

Small Residues Inhibit Homo-Dimerization of the Human Carbonic Anhydrase XII Transmembrane Domain

Membranes, 2021
Amino acids with small side chains and motifs of small residues in a distance of four are rather abundant in human single-span transmembrane helices. While interaction of such helices appears to be common, the role of the small residues in mediating and ...
Florian Cymer, Dirk Schneider
doaj   +1 more source

Modeling the transmembrane domain of bacterial chemoreceptors [PDF]

Protein Science, 2002
AbstractBacterial chemoreceptors signal across the membrane by conformational changes that traverse a four‐helix transmembrane domain. High‐resolution structures are available for the chemoreceptor periplasmic domain and part of the cytoplasmic domain but not for the transmembrane domain.
Megan L, Peach, Gerald L, Hazelbauer, Terry P, Lybrand   +2 more
openaire   +2 more sources

Transmembrane Domains of Attraction on the TSH Receptor [PDF]

Endocrinology, 2014
The TSH receptor (TSHR) has the propensity to form dimers and oligomers. Our data using ectodomain-truncated TSHRs indicated that the predominant interfaces for oligomerization reside in the transmembrane (TM) domain. To map the potentially interacting residues, we first performed in silico studies of the TSHR transmembrane domain using a homology ...
Rauf, Latif, M Rejwan, Ali, Mihaly, Mezei, Terry F, Davies   +3 more
openaire   +2 more sources

Deletion of BST2 Cytoplasmic and Transmembrane N-Terminal Domains Results in SARS-CoV, SARS-CoV-2, and Influenza Virus Production Suppression in a Vero Cell Line

Frontiers in Molecular Biosciences, 2020
SARS-CoV-2, which emerged in Wuhan (China), has become a great worldwide problem in 2020 and has led to more than 1,000,000 deaths worldwide. Many laboratories are searching for ways to fight this pandemic. We studied the action of the cellular antiviral
Alexander A. Dolskiy, Sergei A. Bodnev, Anastasia A. Nazarenko, Anastasia M. Smirnova, Olga G. Pyankova, Anna K. Matveeva, Irina V. Grishchenko, Tatiana V. Tregubchak, Oleg V. Pyankov, Alexander B. Ryzhikov, Elena V. Gavrilova, Rinat A. Maksyutov, Dmitry V. Yudkin   +12 more
doaj   +1 more source

Functional Domains in the Retroviral Transmembrane Protein [PDF]

Journal of Virology, 1998
ABSTRACTThe envelope glycoproteins of the mammalian type C retroviruses consist of two subunits, a surface (SU) protein and a transmembrane (TM) protein. SU binds to the viral receptor and is thought to trigger conformational changes in the associated TM protein that ultimately lead to the fusion of viral and host cell membranes.
Y, Zhao, L, Zhu, C A, Benedict, D, Chen, W F, Anderson, P M, Cannon   +5 more
openaire   +2 more sources