Results 21 to 30 of about 434,631 (260)
Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor. [PDF]
PLoS ONE, 2017 γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and disturbances in the GABAergic system have been implicated in numerous neurological and neuropsychiatric diseases.
Thibaud Freyd +5 more
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Transmembrane domain dependent inhibitory function of FcγRIIB
Protein & Cell, 2018 FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed
Junyi Wang +4 more
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Structural determinants of PINK1 topology and dual subcellular distribution
BMC Cell Biology, 2010 Background PINK1 is a mitochondria-targeted kinase that constitutively localizes to both the mitochondria and the cytosol. The mechanism of how PINK1 achieves cytosolic localization following mitochondrial processing remains unknown.
Kang Un, Lin William
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The CD28 Transmembrane Domain Contains an Essential Dimerization Motif
Frontiers in Immunology, 2020 CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of regulatory T cells.
Scott A. Leddon +5 more
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Interhelical H-Bonds Modulate the Activity of a Polytopic Transmembrane Kinase
Biomolecules, 2021 DesK is a Histidine Kinase that allows Bacillus subtilis to maintain lipid homeostasis in response to changes in the environment. It is located in the membrane, and has five transmembrane helices and a cytoplasmic catalytic domain.
Juan Cruz Almada +5 more
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An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate
eLife, 2014 Membrane protein biogenesis requires the coordinated movement of hydrophobic transmembrane domains (TMD) from the cytosolic vestibule of the Sec61 channel into the lipid bilayer.
Andrew L MacKinnon +4 more
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Calmodulin adopts an extended conformation when interacting with L-selectin in membranes. [PDF]
PLoS ONE, 2013 Calmodulin, an intracellular calcium-binding protein, is thought to regulate ectodomain shedding of many membrane proteins, but the underlying molecular mechanism has remained unclear.
Wei Deng, John A Putkey, Renhao Li
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Molecular Plant-Microbe Interactions, 2006 Hibiscus chlorotic ringspot virus (HCRSV), a member of the genus Carmovirus, encodes p27 (27-kDa protein) and two other in-frame isoforms (p25 and p22.5) that are coterminal at the carboxyl end.
T. Zhou, Z. F. Fan, H. F. Li, S. M. Wong
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A specific interface between integrin transmembrane helices and affinity for ligand. [PDF]
PLoS Biology, 2004 Conformational communication across the plasma membrane between the extracellular and intracellular domains of integrins is beginning to be defined by structural work on both domains.
Bing-Hao Luo +2 more
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NMR Detection and Structural Modeling of the Ethylene Receptor LeETR2 from Tomato
Membranes, 2022 The gaseous plant hormone ethylene influences many physiological processes in plant growth and development. Plant ethylene responses are mediated by a family of ethylene receptors, in which the N-terminal transmembrane domains are responsible for ...
Shukun Wei +5 more
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