Viral Membrane Fusion and the Transmembrane Domain
Viruses, 2020 Initiation of host cell infection by an enveloped virus requires a viral-to-host cell membrane fusion event. This event is mediated by at least one viral transmembrane glycoprotein, termed the fusion protein, which is a key therapeutic target.
Chelsea T. Barrett, Rebecca Ellis Dutch
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NMR Structural Study of Syndecan-4 Transmembrane Domain with Cytoplasmic Region [PDF]
Molecules, 2023 Syndecan-4 (SDC4) consists of transmembrane heparan sulfate proteoglycan (HSPG) belonging to the syndecan family. It is present in most cell types of Mammalia. Its structure contains a heparan-sulfate-modified extracellular domain, a single transmembrane
Minseon Kim, Yongae Kim
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Cells, 2020 Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse effects.
Kento Fujiwara +5 more
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Purification and characterization of the Lassa virus transmembrane domain [PDF]
Biochemistry and Biophysics Reports, 2023 Lassa virus (LASV) is the most prevalent arenavirus afflicting humans and has high potential to become a threat to global public health. The transmembrane domain (TM) of the LASV glycoprotein complex forms critical interactions with the LASV stable ...
Patrick M. Keating +3 more
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Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation [PDF]
Cells, 2023 Interleukin 10 (IL-10) exerts anti-inflammatory and immune regulatory roles through its fixation to the IL-10 receptor (IL-10R). The two subunits (IL-10Rα and IL-10Rβ) organise themselves to form a hetero-tetramer to induce the activation of the ...
Thomas Kuntzel +7 more
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Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion [PDF]
Frontiers in ImmunologyBackgroundAnti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia.
Shufeng Xie +17 more
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Isolated Toll-like receptor transmembrane domains are capable of oligomerization. [PDF]
PLoS ONE, 2012 Toll-like receptors (TLRs) act as the first line of defense against bacterial and viral pathogens by initiating critical defense signals upon dimer activation.
James I Godfroy +4 more
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The transmembrane domain of CEACAM1-4S is a determinant of anchorage independent growth and tumorigenicity. [PDF]
PLoS ONE, 2012 CEACAM1 is a multifunctional Ig-like cell adhesion molecule expressed by epithelial cells in many organs. CEACAM1-4L and CEACAM1-4S, two isoforms produced by differential splicing, are predominant in rat liver. Previous work has shown that downregulation
Erica L Lawson +3 more
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Integrin αIIbβ3 transmembrane domain separation mediates bi-directional signaling across the plasma membrane. [PDF]
PLoS ONE, 2015 Integrins play an essential role in hemostasis, thrombosis, and cell migration, and they transmit bidirectional signals. Transmembrane/cytoplasmic domains are hypothesized to associate in the resting integrins; whereas, ligand binding and intracellular ...
Ping Hu, Bing-Hao Luo
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Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization. [PDF]
PLoS ONE, 2015 RIG-I-like receptors detect viral RNA in infected cells and promote oligomerization of the outer mitochondrial membrane protein MAVS to induce innate immunity to viral infection through type I interferon production. Mitochondrial reactive oxygen species (
Luis Nobre +3 more
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