Results 71 to 80 of about 52,641 (219)

Variable Protease-Sensitive Prionopathy Transmission to Bank Voles

Emerging Infectious Diseases, 2019
Variably protease-sensitive prionopathy (VPSPr), a recently described human sporadic prion disease, features a protease-resistant, disease-related prion protein (resPrPD) displaying 5 fragments reminiscent of Gerstmann-Sträussler-Scheinker disease ...
Romolo Nonno, Silvio Notari, Michele Angelo Di Bari, Ignazio Cali, Laura Pirisinu, Claudia d’Agostino, Laura Cracco, Diane Kofskey, Ilaria Vanni, Jody Lavrich, Piero Parchi, Umberto Agrimi, Pierluigi Gambetti   +12 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Evolution of the SARS‐CoV‐2 Main Protease Under Fitness Constraints Imposed by Folding Stability and Activity

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to evolve and diversify, leading to the emergence of immune‐evasive variants and underscoring the need for complementary antiviral strategies targeting conserved viral machinery. In this context, the main protease (Mpro) represents a potential therapeutic target because
David Ferreiro, Miguel Arenas
wiley   +1 more source

Epidemiological drivers of turnip yellows virus and its vector Myzus persicae in Australian canola (Brassica napus) systems: a 3‐year study of commercial crops and noncrop vegetation

Pest Management Science, EarlyView.
A 3‐year study across southern Australia aimed to characterize drivers of infection in the Myzus persicae–turnip yellows virus–Brassica napus pathosystem. Identification of key reservoir hosts and the strong association between earlier sowing and increased disease incidence highlight opportunities for targeted weed management, strategic sowing ...
Samantha E Edley, Owain R Edwards, Benjamin S Congdon, John G Black, Marielle Babineau, Anthony R van Rooyen, Alex Slavenko, Roger AC Jones, Andrew R Weeks, Paul A Umina   +9 more
wiley   +1 more source

Single and dual RPA‐CRISPR/Cas assays for point‐of‐need detection of Stewart's wilt pathogen (Pantoea stewartii subsp. stewartii) of corn and Maize dwarf mosaic virus

Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.
Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian, Hua Zhou, Zhenxing Zhao, Yongjiang Zhang, Wenjun Zhao, Lulu Cai, Tao Guo   +6 more
wiley   +1 more source

Facing Obsolescence: Component Repair and Collaboration in the Independent ICT Commercial Repair Sector

Sustainable Development, EarlyView.
ABSTRACT Repairs are becoming more difficult to perform due to multiple factors, including obsolescence, complexity of designs, technological change and lack of information and spare parts. This underlines a conflict between repair and technological designs driven by accumulation logics that require increasing growth rates.
Francisco López‐Bermúdez, Xavier Vence   +1 more
wiley   +1 more source

Bioactive Gold Plasmonic Interfaces Meet Artificial Intelligence: Advancing Saliva‐Based Surface‐Enhanced Raman Spectroscopy Diagnostics

Small, EarlyView.
ABSTRACT Bioactive gold plasmonic nanostructures are enabling non‐invasive saliva diagnostics by amplifying weak Raman signals and converting complex biofluid chemistry into information‐rich spectral fingerprints. This Review examines saliva‐based Raman and surface‐enhanced Raman spectroscopy (SERS) integrated with artificial intelligence (AI) from a ...
Ajitesh Dhal, Ana Elena Aviña, Nguyen Le Thanh Hang, Pei‐Wen Peng, Cheng‐Jen Chang, Tzu‐Sen Yang   +5 more
wiley   +1 more source

Epileptic–Dyskinetic Encephalopathy Associated with a PPP3CA Variant: Expansion of the Phenotypic Spectrum

Movement Disorders Clinical Practice, EarlyView.
Bruno Antunes Contrucci, Ursula Thomé, Larissa Aparecida Batista, Ana Laura Volpi Martins Lorenzoni, Carla Andrea Cardoso Tanuri Caldas, Americo Ceiki Sakamoto, Israel Gomy, Lisandra Mesquita Batista, Marcela Lopes de Almeida, Ana Paula Andrade Hamad, Guillermo Andrey Ariza Traslaviña   +10 more
wiley   +1 more source

A South African Language Teacher Educator's Reflective Journey Through Sociocultural Theory and Asset‐Based Mediation

TESOL Quarterly, EarlyView.
Abstract This reflective article chronicles a South African English as a Medium of Instruction (EMI) university teacher educator's journey from professional disillusionment toward a more intentional, transformative praxis. The catalyst for this journey was the recurring observation of novice teachers abandoning dialogic, asset‐based pedagogies learned ...
Nhlanhla Mpofu
wiley   +1 more source

Various vehicle speeds and road profiles effects on transmitted accelerations analysis to human body segments using vehicle and biomechanical models

Cogent Engineering, 2018
In this paper, a biomechanical model of human body is proposed to evaluate the biodynamic responses to vertical vibration and transmitted accelerations for the seated position without backrest support.
Somaye Jamali Shakhlavi, Javad Marzbanrad, Vahid Tavoosi   +2 more
doaj   +1 more source