Results 31 to 40 of about 1,679,372 (245)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

GCFR: graph contrastive fault representation for robust diagnosis in power communication networks

Scientific Reports
This work addresses fault diagnosis in power communication networks (PCNs) under three practical challenges–limited labels, evolving topology, and noisy alarms–by proposing GCFR, a graph-contrastive fault representation framework. GCFR learns robust node
Baohao Chen, Guosheng Lu, Yifeng Zhu, Chengyu Liu, Bingdong Qin, Jianxue Li   +5 more
doaj   +1 more source

Comparative genomics and evolution of regulons of the LacI-family transcription factors

Frontiers in Microbiology, 2014
DNA-binding transcription factors (TFs) are essential components of transcriptional regulatory networks in Bacteria. LacI-family TFs (LacI-TFs) are broadly distributed among certain lineages of bacteria. The majority of characterized LacI-TFs sense sugar
Dmitry A Ravcheev, Matvei S Khoroshkin, Olga N Laikova, Olga V Tsoy, Natalia V Sernova, Svetlana A Petrova, Aleksandra B Rakhmaninova, Pavel S Novichkov, Mikhail S Gelfand, Mikhail S Gelfand, Dmitry A Rodionov, Dmitry A Rodionov   +11 more
doaj   +1 more source

Calculation of inlet capacitance for long-duration induction voltage test of single-phase three-winding converter transformers

Energy Reports, 2023
The converter transformer is one of the core equipment in the high-voltage DC (HVDC) transmission project. The capacity of the converter transformer is much larger than that of an ordinary AC transformer, and its main function is to convert the AC system
Shijie Li, Jinzhuang Lv, Jiankun Wang, Jinzhou Xiong, Xinbo Zhang, Xuzhe Li   +5 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Experimental verification of mobility modeling for N-polar GaN HEMTs [PDF]

AIP Advances
N-polar GaN high-electron-mobility transistors (HEMTs) show unique transfer characteristics originating from the band structure related to the inverted HEMTs, and some scattering mechanisms are suggested theoretically.
Akira Mukai, Shigeki Yoshida, Junya Yaita, Akihiro Hayasaka, Maui Hino, Junji Kotani, Kozo Makiyama, Ken Nakata   +7 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Trans2express – de novo transcriptome assembly pipeline optimized for gene expression analysis

Plant Methods
Background As genomes of many eukaryotic species, especially plants, are large and complex, their de novo sequencing and assembly is still a difficult task despite progress in sequencing technologies.
Aleksandra M. Kasianova, Aleksey A. Penin, Mikhail I. Schelkunov, Artem S. Kasianov, Maria D. Logacheva, Anna V. Klepikova   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Sugar Lego: gene composition of bacterial carbohydrate metabolism genomic loci

Biology Direct, 2017
Background Bacterial carbohydrate metabolism is extremely diverse, since carbohydrates serve as a major energy source and are involved in a variety of cellular processes.
Anna Kaznadzey, Pavel Shelyakin, Mikhail S. Gelfand   +2 more
doaj   +1 more source