Results 71 to 80 of about 507,347 (315)

On the Energy Efficiency of Dual Clutch Transmissions and Automated Manual Transmissions [PDF]

Energies, 2017
The main benefits of dual clutch transmissions (DCTs) are: (i) a higher energy efficiency than automatic transmission systems with torque converters; and (ii) the capability to fill the torque gap during gear shifts to allow seamless longitudinal acceleration profiles.
Vacca F., De Pinto S., Karci A. E. H., Gruber P., Viotto F., Cavallino C., Rossi J., Sorniotti A.   +7 more
openaire   +5 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Modeling and Analysis of Transmission Efficiency for 3K Planetary Gearbox with Flexure-Based Carrier for Backdrivable Robot Joints

Actuators
A high-gear-ratio anti-backlash 3K planetary gearbox with a preloaded flexure-based carrier is a suitable reducer for robot joints owning to its compact design and high transmission accuracy.
Qinghao Du, Guilin Yang, Weijun Wang, Chin-Yin Chen, Zaojun Fang   +4 more
doaj   +1 more source

Research on Transmission Characteristic of ZF 9-speed Automatic Transmission

, 2021
Taking the ZF 9-speed automatic transmission (9HP48) as the research object，the power transmission line in each gear of the automatic transmission is clarified.
Junyu Cai, Xin Fan, Junyan Wang
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Content‐Based Efficient Messages Transmission in WSNs [PDF]

Wireless Communications and Mobile Computing, 2018
The WSNs are mainly to monitor various types of sensing content. In the automated control system, administration centers (ACs) often send notifications to a set of nodes meeting given content ranges to implement specific actions. For instance, we notify the sensing devices with sensing temperatures greater than 35 to turn on the cooling system.
Rong Xiao 0002, Bo Sun 0006, Yongkang Xiao, Yungang Wei, Wenlong Chen   +4 more
openaire   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Calculation and Research of Transmission Efficiency of Gear with Addendum Modification based on Roll-off Angle

, 2015
Based on the power method,the roll-off angle is introduced to measure the position of meshing point,and the function relation formula between the modification coefficient and meshing efficiency is derived.The calculation formulation of modification ...
Tang Jinyuan, Wang Yixinyu
core   +1 more source