Results 81 to 90 of about 1,459,435 (339)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Metamaterial Polarization Converter Analysis: Limits of Performance

, 2012
In this paper we analyze the theoretical limits of a metamaterial converter that allows for linear-to- elliptical polarization transformation with any desired ellipticity and ellipse orientation.
A. Drezet, A. Pors, A. Roberts, A.C. Strikwerda, A.C. Strikwerda, Andrei Andryieuski, Andrei V. Lavrinenko, C. Sabah, D. Molter, D.-H. Kwon, Dmitry L. Markovich, F. Wang, J. Hao, J. Hao, J.B. Masson, J.K. Gansel, J.Y. Chin, J.Y. Chin, M. Mutlu, M. Tonouchi, Maksim Zalkovskij, P. Weis, P.U. Jepsen, R. Singh, Radu Malureanu, S.C Saha, S.X. Li, T. Arikawa, T. Kleine-Ostmann, T. Li, W. Sun, X.G. Peralta, Y. Zhao   +32 more
core   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Energy efficiency of information transmission by electrically coupled neurons

, 2012
The generation of spikes by neurons is energetically a costly process. This paper studies the consumption of energy and the information entropy in the signalling activity of a model neuron both when it is supposed isolated and when it is coupled to ...
Abarbanel, Abdelmalik Moujahid, Alicia d’Anjou, Attwell, Balasubramanian, Belykh, Cecilia Sarasola, Clarke, Connors, Dhamala, Donald, FitzHugh, Francisco J. Torrealdea, Galarreta, Hansel, Hasegawa, Hayashi, Herz, Hindmarsh, Hodgkin, Huerta, Kasischke, Kepler, Koch, Kolb, Lago-Fernandez, Laughlin, Lennie, Levy, Levy, Mackay, Morrison, N. Vélez de Mendizábal, Nagai, Nemenman, Olver, Ozden, Pinto, Rieke, Rose, Rose, Rose, Rose, Rosenblum, Roy, Rulkov, Sarasola, Schreiber, Selverston, Shannon, Siekevitz, Smith, Strong, Torrealdea, Torrealdea, Venaille, Veruki, Veruki, Vincent, Wu, Yoshioka   +60 more
core   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao, Rongwei Du, Zhujun Wang, Yang Gao, Meiling Cheng, Xianglong Wang, Wen Wu   +6 more
wiley   +1 more source

Exploring Bemisia tabaci Middle East–Asia Minor I and Mediterranean Cryptic Species Relationship with Cowpea Mild Mottle Virus and Their Dynamics in Soybean Fields

Insects
Cowpea mild mottle virus (CPMMV, genus Carlavirus, family Betaflexividae) is an economically important virus infecting soybeans in Brazil, where it was initially identified in 1983.
Felipe Barreto da Silva, Rodrigo de Sarandy Raposo, Sarah Forlani de Campos, Juliana Uzan, Julio Massaharu Marubayashi, Marcos Roberto Ribeiro-Junior, Angélica Maria Nogueira, Caroline da Cruz Martines, Vinicius Henrique Bello, Cristiane Müller, Maria Márcia Pereira Sartori, Renate Krause-Sakate   +11 more
doaj   +1 more source

Numerical analysis of high-index nanocomposite encapsulant for light-emitting diodes

, 2005
We used two-dimensional Finte-Difference-Time-Domain (FDTD) software to study the transition behavior of nano-particles from scatterers to an optically uniform medium.
Almuneau, Guilhem, Ju, Young-Gu, Kim, Tae-Hoon, Lee, Baek-Woon   +3 more
core   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source