Results 31 to 40 of about 709,315 (265)

Approach for the Calculation of Transmission Ratios and Their Errors in 4-Bar Mechanisms, Considering the Precision Variations by Dimensional Tolerances

AppliedMath
This paper presents research and theoretical development of a mathematical model that, first, allows us to understand how the positional exactitude of the output link of a four-bar mechanism depends on the manufacturing dimensional tolerances.
Javier Flores Méndez, Gustavo M. Minquiz, Alfredo Morales-Sánchez, Mario Moreno, Zaira Jocelyn Hernández Simón, José Alberto Luna López, Francisco Severiano Carrillo, Luis Hernández Martínez, Nancy E. González Sierra, Ana Cecilia Piñón Reyes   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Dual Cone Continuously Variable Transmission Model Controlled by LabVIEW

Machines
This paper outlines the design, development, and practical implementation of a rubber belt-driven dual cone continuously variable transmission (CVT) model. This model enables a demonstration of stepless changes in the transmission ratio between input and
Šimon Berta, Vladimír Goga, Kristián Ondrejička, Erik Kučera, Vladimír Kutiš   +4 more
doaj   +1 more source

Spam1-associated transmission ratio distortion in mice: Elucidating the mechanism

Reproductive Biology and Endocrinology, 2005
Background While transmission ratio distortion, TRD, (a deviation from Mendelian ratio) is extensive in humans and well-documented in mice, the underlying mechanisms are unknown.
Barnoski Barry L, Rulon Michelle, Zhao Yutong, Morales Carlos R, Zhang Hong, Martin-DeLeon Patricia A, Chen Hong, Galileo Deni S   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Research on Meshing Efficiency of Gear Pairs Based on Dynamic Sliding Friction Factors

Jixie chuandong, 2023
In order to study the meshing efficiency of the gear pair under the actual working conditions, the force and kinematics of the contact surface of the gear pair are analyzed, the lubrication state of the gear pair is judged by combining the theory of ...
Fu Jingbo, Qiao Mingming, Guo Zhili, Chen Jiangyi   +3 more
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Two-Speed Transmission Structure and Optimization Design for Electric Vehicles

Machines, 2023
The trend in the global automotive industry is moving towards electric vehicles that do not emit exhaust gases and use eco-friendly fuel. Electric vehicles are more eco-friendly compared to internal combustion engine vehicles, as they emit less carbon ...
Wonhyeong Jeong, Jaeoh Han, Taesu Kim, Jongseok Lee, Sehoon Oh   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source