Results 41 to 50 of about 762,423 (308)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of strain and inoculation dose of classical swine fever virus on within-pen transmission.

, 2009
To improve the understanding of the dynamics and options for control of classical swine fever (CSF), more quantitative knowledge is needed on virus transmission.
Loeffen, W.L.A., Backer, J.A., Stegeman, J.A., Weesendorp, E.   +3 more
core   +1 more source

Investigation of Drive Performance of Motors in Electric Loaders with Unequal Transmission Ratios—A Case Study

World Electric Vehicle Journal
Research on electric wheel loaders (EWLs) has predominantly focused on battery management, hybrid technologies, and energy recovery. However, the influence of motor types and drivetrains on the drive performance of EWLs has received little attention in ...
Xiaotao Fei, Shaw Voon Wong, Muhammad Amin Azman, Peng Liu, Yunwu Han   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Dual Cone Continuously Variable Transmission Model Controlled by LabVIEW

Machines
This paper outlines the design, development, and practical implementation of a rubber belt-driven dual cone continuously variable transmission (CVT) model. This model enables a demonstration of stepless changes in the transmission ratio between input and
Šimon Berta, Vladimír Goga, Kristián Ondrejička, Erik Kučera, Vladimír Kutiš   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Approach for the Calculation of Transmission Ratios and Their Errors in 4-Bar Mechanisms, Considering the Precision Variations by Dimensional Tolerances

AppliedMath
This paper presents research and theoretical development of a mathematical model that, first, allows us to understand how the positional exactitude of the output link of a four-bar mechanism depends on the manufacturing dimensional tolerances.
Javier Flores Méndez, Gustavo M. Minquiz, Alfredo Morales-Sánchez, Mario Moreno, Zaira Jocelyn Hernández Simón, José Alberto Luna López, Francisco Severiano Carrillo, Luis Hernández Martínez, Nancy E. González Sierra, Ana Cecilia Piñón Reyes   +9 more
doaj   +1 more source

Spam1-associated transmission ratio distortion in mice: Elucidating the mechanism

Reproductive Biology and Endocrinology, 2005
Background While transmission ratio distortion, TRD, (a deviation from Mendelian ratio) is extensive in humans and well-documented in mice, the underlying mechanisms are unknown.
Barnoski Barry L, Rulon Michelle, Zhao Yutong, Morales Carlos R, Zhang Hong, Martin-DeLeon Patricia A, Chen Hong, Galileo Deni S   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source