Results 41 to 50 of about 209,138 (268)

Intrafamilial Transmission and Family-Specific Spectra of Cutaneous Betapapillomaviruses [PDF]

Journal of Virology, 2009
ABSTRACT Cutaneous human betapapillomaviruses (beta-HPVs) are widespread in the general population and have been associated with skin cancer. To evaluate the impact of continuous person-to-person contact within families on an individual's beta-HPV type spectrum, we collected serial skin swab samples from parents and children from 10 families.
S J, Weissenborn, M N C, De Koning, U, Wieland, W G V, Quint, H J, Pfister   +4 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Morphology and optical properties of CdS thin films prepared by Physical Vapor Deposition method

Фізика і хімія твердого тіла, 2022
The optical properties of cadmium sulfide thin films obtained by thermal evaporation in vacuum were studied. The stoichiometric compositions of the binary compound previously synthesized from high-purity powders of the initial components were used. Films
I.V. Vakaliuk, R.S. Yavorskiy, L.I. Nykyruy, B.P. Naidych, Ya.S. Yavorskyy   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Improved Numerical Calculation of the Single-Mode-No-Core-Single-Mode Fiber Structure Using the Fields Far from Cutoff Approximation

Sensors, 2017
Multimode interferometers based on the single-mode-no-core-single-mode fiber (SNCS) structure have been widely investigated as functional devices and sensors.
Wei Xu, Jia Shi, Xianchao Yang, Degang Xu, Feng Rong, Junfa Zhao, Jianquan Yao   +6 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Electronic properties and quantum transport behavior of twisted γ-graphdiyne/graphene

National Science Open
Van der Waals heterostructures are acknowledged as a decent platform for electronic and optoelectronic applications owing to their atomically flat interfaces, unprecedented flexibility and unique physical characteristics.
Liu Yingcong, Bai Haokun, Wang Xin, Sun Haochun, Xiong Zhaozhao, Dai Fulong, Liang Zhuojian, Kang Zhuo, Zhang Yue   +8 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

CLOUD BASE SIGNATURE IN TRANSMISSION SPECTRA OF EXOPLANET ATMOSPHERES [PDF]

The Astrophysical Journal, 2014
We present an analytical model for the transmission spectrum of a transiting exoplanet, showing that a cloud base can produce an observable inflection point in the spectrum. The wavelength and magnitude of the inflection can be used to break the degeneracy between the atmospheric pressure and the abundance of the main cloud material, however, the ...
Vahidinia, Sanaz, Cuzzi, Jeffrey N., Marley, Mark, Fortney, Jonathan   +3 more
openaire   +2 more sources