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Persistence of HIV-1 transmitted drug resistance mutations. [PDF]

Journal of Infectious Diseases, 2013
There are few data on the persistence of individual human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) mutations in the absence of selective drug pressure. We studied 313 patients in whom TDR mutations were detected at their first resistance test and who had a subsequent test performed while ART-naive.
Chloe Orkin, Kate Templeton, Brendan Payne   +2 more
exaly   +5 more sources

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Transmitted HIV drug resistance in Asia

Current Opinion in HIV and AIDS, 2013
Surveillance for transmitted HIV drug resistance is essential to assessing the longer term sustainability and durability of first-line antiretroviral therapy (ART). Increases in pre-ART resistance would compromise the ability to achieve optimal and durable treatment outcomes using currently recommended antiretrovirals.In the Asia region, many countries
Annette H, Sohn, Padmini, Srikantiah, Somnuek, Sungkanuparph, Fujie, Zhang   +3 more
openaire   +2 more sources

Transmitted HIV drug resistance in treatment-naive Romanian patients [PDF]

Journal of Medical Virology, 2013
AbstractTransmitted HIV drug resistance (TDR) remains an important concern for individuals unexposed to antiretroviral treatment. Data on the prevalence of TDR, available mainly for HIV‐1 subtype B, are now also emerging for other subtypes. In Romania, a steady predominance of subtype F was reported among both long‐term survivor children and newly ...
Loredana Sabina Cornelia Manolescu, Simona Ruta   +1 more
exaly   +3 more sources

Transmitted HIV Drug Resistance Is High and Longstanding in Metropolitan Washington, DC. [PDF]

Clinical Infectious Diseases, 2016
Washington, DC, has 2.5% human immunodeficiency virus (HIV) prevalence, 3.9% among African Americans. Antiretrovirals (ARTs) are the cornerstone for treatment and prevention. Monitoring changes in transmitted drug resistance (TDR) is critical for effective HIV care.HIV genotype data for individuals enrolled in research studies in metropolitan ...
Irini Sereti, Frank Maldarelli, Princy N Kumar   +2 more
exaly   +3 more sources

Epidemiological aspects of transmitted HIV drug resistance

Scandinavian Journal of Infectious Diseases, 2003
Transmitted human immunodeficiency virus (HIV) resistance to antiretrovirals (i.e. resistance in antiretroviral naive patients) emerged during the 1990s as a potentially relevant public health problem. HIV variants resistant to all classes of approved antiretroviral agents have been identified in significant proportions antiretroviral naive patients ...
openaire   +2 more sources

Improving systems to monitor transmitted HIV drug resistance

BMJ, 2012
Surveillance systems need strengthening to ensure greater consistency and comparability of ...
openaire   +2 more sources

Stability of transmitted drug-resistant HIV-1 species

Current Opinion in Infectious Diseases, 2005
The proportion of patients showing primary infection with HIV-1 that are already resistant to antiviral drugs has been steadily increasing. Such resistance is known to compromise therapy response. Most patients, however, are not diagnosed during their incident infection and, until recently, it was not known for how long resistant virus can be detected ...
openaire   +2 more sources

Tracking the Prevalence of Transmitted Antiretroviral Drug-Resistant HIV-1

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2006
Transmitted resistance to antiretroviral drugs in acute and early HIV-1 infection has been well documented, although overall trends vary depending on geography and cohort characteristics. To describe the changing pattern of transmitted drug-resistant HIV-1 in a well-defined cohort in New York City, a total of 361 patients with acute or recent HIV-1 ...
Anita, Shet, Leslie, Berry, Hiroshi, Mohri, Saurabh, Mehandru, Chris, Chung, Alexandria, Kim, Patrick, Jean-Pierre, Christine, Hogan, Viviana, Simon, Daniel, Boden, Martin, Markowitz   +10 more
openaire   +2 more sources

Evidence of a decline in transmitted HIV-1 drug resistance in the United Kingdom

AIDS, 2007
To examine recent trends in transmitted drug resistance (TDR) in the United Kingdom.Analysis of results of genotypic resistance tests reported to the UK HIV Drug Resistance Database, which includes virtually all tests conducted as part of routine clinical care nationally. Resistance was based on major mutations as defined in the 2005 International AIDS
Burns, S., Cameron, S., Cane, P., Chrystie, I., Churchill, D., Delpech, V., Pillay, D., Dunn, D., Fearnhill, E., Green, H., Porter, K., Easterbrook, P., Zuckerman, M., Geretti, A. M., Gifford, R., Kellam, P., Phillips, A., Sabin, C., Goldberg, D., Gompels, M., Hale, A., Kaye, S., Leigh-Brown, A., Orkin, C., Pozniak, A., Robb, G., Smit, E., Tilston, P., Williams, I.   +28 more
openaire   +4 more sources