Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis. [PDF]
Am J Respir Crit Care Med, 2018 Abstract Rationale Acquired resistance is an important driver of multidrug-resistant tuberculosis (TB), even with good treatment adherence.
Dheda K +18 more
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Suppression of Chromosome Instability Limits Acquired Drug Resistance. [PDF]
Mol Cancer Ther, 2022 Abstract Numerical chromosome instability, or nCIN, defined as the high frequency of whole chromosome gains and losses, is prevalent in many solid tumors. nCIN has been shown to promote intra-tumor heterogeneity and corresponds with tumor aggressiveness, drug resistance and tumor relapse. While increased nCIN has been
Crowley EA +3 more
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Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein [PDF]
Pharmaceuticals, 2021 Multidrug-Resistant (MDR) cancers attenuate chemotherapeutic efficacy through drug efflux, a process that transports drugs from within a cell to the extracellular space via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ...
Anunay J. Pulukuri +6 more
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The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis [PDF]
Cancer Reports, 2022 Background Cancer emergence is associated with a series of cellular transformations that include acquired drug resistance followed by tumor metastasis.
Pankaj Kumar +2 more
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The Integration of Proteomics and Metabolomics Data Paving the Way for a Better Understanding of the Mechanisms Underlying Microbial Acquired Drug Resistance [PDF]
Frontiers in Medicine, 2022 Due to an increase in the overuse of antimicrobials and accelerated incidence of drug resistant pathogens, antimicrobial resistance has become a global health threat.
Suereta Fortuin +2 more
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Long-term stability of acquired drug resistance and resistance associated mutations in the fungal pathogen Nakaseomyces glabratus (Candida glabrata) [PDF]
Frontiers in Cellular and Infection MicrobiologyThe limited number of available antifungal drugs and the increasing number of fungal isolates that show drug or multidrug resistance pose a serious medical threat.
Ewa Ksiezopolska +9 more
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Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response [PDF]
Frontiers in ImmunologyIntroductionBreast cancer is a significant public health problem around the world, ranking first in deaths due to cancer in females. The therapy to fight breast cancer involves different methods, including conventional chemotherapy. However, the acquired
Patrick Santos +8 more
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Overcoming Acquired Drug Resistance to Cancer Therapies through Targeted STAT3 Inhibition. [PDF]
Int J Mol Sci, 2023 Singh S +4 more
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EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance [PDF]
Cancers, 2021 The epidermal growth factor receptor (EGFR) has served as the founding member of the large family of growth factor receptors harboring intrinsic tyrosine kinase function. High abundance of EGFR and large internal deletions are frequently observed in brain tumors, whereas point mutations and small insertions within the kinase domain are common in lung ...
Uribe M. L., Marrocco I., Yarden Y.
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Acquired Resistance to Antibody-Drug Conjugates [PDF]
Cancers, 2019 Antibody-drug conjugates (ADCs) combine the tumor selectivity of antibodies with the potency of cytotoxic small molecules thereby constituting antibody-mediated chemotherapy. As this inherently limits the adverse effects of the chemotherapeutic, such approaches are heavily pursued by pharma and biotech companies and have resulted in four FDA (Food and ...
Denis Collins +3 more
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