Results 1 to 10 of about 3,736 (70)

Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein

Pharmaceuticals, 2021
Multidrug-Resistant (MDR) cancers attenuate chemotherapeutic efficacy through drug efflux, a process that transports drugs from within a cell to the extracellular space via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ...
Anunay J. Pulukuri, Anthony J. Burt, Larissa K. Opp, Colin M. McDowell, Maryam Davaritouchaee, Amy E. Nielsen, Rock J. Mancini   +6 more
doaj   +1 more source

Immune Disorders in Patients with Pulmonary Tuberculosis with Primary and Acquired Drug-Resistance of Mycobacterium Tuberculosis

Туберкулез и болезни лёгких, 2022
The objective: to evaluate main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological ...
E. Lesnik, S. Ginda
doaj   +1 more source

The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS

Antioxidants, 2021
The characteristics of phthalates had been thought to be similar to endocrine disruptors, which increases cancer risk. The role of phthalates in acquired drug resistance remains unclear.
Mahendra Jadhao, Eing-Mei Tsai, Ho-Chun Yang, Yih-Fung Chen, Shih-Shin Liang, Tsu-Nai Wang, Yen-Ni Teng, Hurng-Wern Huang, Li-Fang Wang, Chien-Chih Chiu   +9 more
doaj   +1 more source

The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis

Cancer Reports, 2022
Background Cancer emergence is associated with a series of cellular transformations that include acquired drug resistance followed by tumor metastasis.
Pankaj Kumar, Satish Siripini, Amere Subbarao Sreedhar   +2 more
doaj   +1 more source

Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer

Frontiers in Pharmacology, 2021
Although chemotherapy, targeted therapy and endocrine therapy decrease rate of disease recurrence in most breast cancer patients, many patients exhibit acquired resistance.
Chao Dong, Jiao Wu, Yin Chen, Jianyun Nie, Ceshi Chen, Ceshi Chen   +5 more
doaj   +1 more source

Loss of MHC-I antigen presentation correlated with immune checkpoint blockade tolerance in MAPK inhibitor-resistant melanoma

Frontiers in Pharmacology, 2022
Immune checkpoint blockade and MAPK-targeted combined therapy is a promising regimen for advanced melanoma patients. However, the clinical benefit from this combo regimen remains limited, especially in patients who acquired resistance to MAPK-targeted ...
Jing Yu, Xi Wu, Jinen Song, Yujie Zhao, Huifang Li, Min Luo, Xiaowei Liu   +6 more
doaj   +1 more source

Clinical utility of PDX cohorts to reveal biomarkers of intrinsic resistance and clonal architecture changes underlying acquired resistance to cetuximab in HNSCC

Signal Transduction and Targeted Therapy, 2022
Cetuximab is a widely used drug for treating head and neck squamous cell carcinomas (HNSCCs); however, it provides restricted clinical benefits, and its response duration is limited by drug resistance.
Yanli Yao, Yujue Wang, Lan Chen, Zhen Tian, Guizhu Yang, Rui Wang, Chong Wang, Qi Wu, Yaping Wu, Jiamin Gao, Xindan Kang, Shengzhong Duan, Zhiyuan Zhang, Shuyang Sun   +13 more
doaj   +1 more source

Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000–2015

Emerging Infectious Diseases, 2018
Among tuberculosis (TB) patients, acquired resistance to anti-TB drugs represents a failure in the treatment pathway. To improve diagnosis and care for patients with drug-resistant TB, we examined the epidemiology and risk factors associated with ...
Miranda G. Loutet, Jennifer A. Davidson, Tim Brown, Martin Dedicoat, H. Lucy Thomas, Maeve K. Lalor   +5 more
doaj   +1 more source

Risk Factors for Acquisition of Drug Resistance during Multidrug-Resistant Tuberculosis Treatment, Arkhangelsk Oblast, Russia, 2005–2010

Emerging Infectious Diseases, 2015
Acquired resistance to antituberculosis drugs decreases effective treatment options and the likelihood of treatment success. We identified risk factors for acquisition of drug resistance during treatment for multidrug-resistant tuberculosis (MDR TB) and ...
Sarah E. Smith, Julia Ershova, Natalia Vlasova, Elena Nikishova, Irina Tarasova, Platon Eliseev, Andrey Maryandyshev, Igor G. Shemyakin, Ekaterina V. Kurbatova, J. Peter Cegielski   +9 more
doaj   +1 more source

Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance

Biomedicines, 2022
Acquired drug resistance represents a major clinical problem and one of the biggest limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using standard chemotherapeutic agents, together with bioactive natural compounds ...
Laura Ioana Gavrilas, Daniel Cruceriu, Andrei Mocan, Felicia Loghin, Doina Miere, Ovidiu Balacescu   +5 more
doaj   +1 more source