Results 41 to 50 of about 370,457 (256)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Chromosomal instability and acquired drug resistance in multiple myeloma

Oncotarget, 2017
Chromosomal instability (CIN) is an important hallmark of human cancer. CIN not only contributes to all stages of tumor development (initiation, promotion and progression) but also drives, in large measure, the acquisition of drug resistance by cancer cells.
Wang, Wang, Zhang, Yi, Chen, Ruini, Tian, Zhidan, Zhai, Yongpin, Janz, Siegfried, Gu, Chunyan, Yang, Ye   +7 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Exploiting acquired vulnerability to develop novel treatments for cholangiocarcinoma

Cancer Cell International
Cholangiocarcinoma (CCA) presents a formidable therapeutic challenge due to its extensive heterogeneity and plasticity, which inevitably lead to acquired resistance to current treatments. However, recent evidence suggests that acquired drug resistance is
Sirayot Areewong, Orawan Suppramote, Sunisa Prasopporn, Siwanon Jirawatnotai   +3 more
doaj   +1 more source

Future of Antiretroviral Drugs and Evolution of HIV-1 Drug Resistance

Viruses, 2023
Highly active antiretroviral (ARV) therapy has been used for many years, but the use in low- and middle-income countries of antiretroviral drugs with low genetic barrier to resistance, combined with limited availability of viral load testing, has led to ...
Charlotte Charpentier, Quentin Le Hingrat, Valentine Marie Ferré, Florence Damond, Diane Descamps   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Drug resistance in community-acquired respiratory tract infections: role for an emerging antibacterial

Infection and Drug Resistance, 2010
Lorenzo Aguilar1, María-José Giménez1, José Barberán21Microbiology Department, School of Medicine, University Complutense, Madrid; 2Infectious Diseases Department, Hospital Central de la Defensa ...
Lorenzo Aguilar, María-José Giménez, José Barberán   +2 more
doaj  

Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid

Clinical Infectious Diseases, 2020
Abstract This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate.
Takashi Yoshiyama, Akiko Takaki, Akio Aono, Satoshi Mitarai, Masao Okumura, Ken Ohta, Seiya Kato   +6 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Five-year trend of acquired antitubercular drug resistance in patients attending a tertiary care hospital at Dehradun (Uttarakhand)

Lung India, 2009
Background/Aim: To study the prevalence and trend of acquired drug resistance to the first line antitubercular drugs . Materials and Methods: Sputum of 215 previously treated adult pulmonary tuberculosis (TB) patients over a period of 2002-2006 were ...
Rawat Jagdish, Sindhwani G, Dua Ruchi
doaj