Results 51 to 60 of about 370,457 (256)

Integrative genomic analysis of drug resistance in MET exon 14 skipping lung cancer using patient-derived xenograft models

Frontiers in Oncology, 2022
BackgroundNon-small cell lung cancer (NSCLC) driven by MET exon 14 skipping (METex14) occurs in 3-4% of NSCLC cases and defines a subset of patients with distinct characteristics.
Yunhua Xu, Linping Gu, Yingqi Li, Ruiying Zhao, Hong Jian, Wenhui Xie, Liu Liu, Huiwen Wu, Fang Ren, Yuchen Han, Shun Lu   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Transmission is a Noticeable Cause of Resistance Among Treated Tuberculosis Patients in Shanghai, China

Scientific Reports, 2017
It is generally believed that drug resistance among treated tuberculosis (TB) patients is as a result of acquired drug resistance due to inappropriate treatment. Previous studies have shown that primary drug resistance caused by transmission also plays a
Chijioke A. Nsofor, Qi Jiang, Jie Wu, Mingyu Gan, Qingyun Liu, Tianyu Zuo, Guofeng Zhu, Qian Gao   +7 more
doaj   +1 more source

Association between Mycobacterium tuberculosis complex phylogenetic lineage and acquired drug resistance.

PLoS ONE, 2013
BackgroundDevelopment of resistance to antituberculosis drugs during treatment (i.e., acquired resistance) can lead to emergence of resistant strains and consequent poor clinical outcomes. However, it is unknown whether Mycobacterium tuberculosis complex
Courtney M Yuen, Ekaterina V Kurbatova, Eleanor S Click, J Sean Cavanaugh, J Peter Cegielski   +4 more
doaj   +1 more source

Primary and acquired multidrug-resistant tuberculosis: Predictive factors for unfavorable treatment outcomes in Rio de Janeiro, 2000–2016

Revista Panamericana de Salud Pública, 2020
Objective. To identify clinical and demographic factors associated with unfavorable treatment outcomes in patients with primary and acquired multidrug-resistant tuberculosis (MDR-TB) in Rio de Janeiro State. Methods. Retrospective cohort study using data
Marcela Bhering, Afrânio Kritski
doaj   +1 more source

Research Progress on the Combination Therapy of EGFR-TKIs and Metformin 
in Acquired Resistance to EGFR-TKIs in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) targeting EGFR are effective in EGFR mutation-positive non-small cell lung cancer (NSCLC) patients, but drug resistance is inevitable.
Jiamin WANG, Pan LIU, Lisha YING, Rui ZHU, Chaodan YANG, Ying YANG, Dan SU   +6 more
doaj   +1 more source

Acquired resistance to drugs targeting receptor tyrosine kinases [PDF]

Biochemical Pharmacology, 2012
Development of resistance to chemotherapeutic drugs represents a significant hindrance to the effective treatment of cancer patients. The molecular mechanisms responsible have been investigated for over half a century and have revealed the lack of a single cause.
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase

Cell Reports, 2015
Protein kinases are therapeutic targets for human cancer. However, “gatekeeper” mutations in tyrosine kinases cause acquired clinical resistance, limiting long-term treatment benefits. mTOR is a key cancer driver and drug target.
Tzung-Ju Wu, Xiaowen Wang, Yanjie Zhang, Linghua Meng, John E. Kerrigan, Stephen K. Burley, X.F. Steven Zheng   +6 more
doaj   +1 more source