Results 51 to 60 of about 4,548,181 (253)
A research‐inspired laboratory sequence investigating acquired drug resistance [PDF]
Biochemistry and Molecular Biology Education, 2010 AbstractHere, we present a six‐session laboratory exercise designed to introduce students to standard biochemical techniques in the context of investigating a high impact research topic, acquired resistance to the cancer drug Gleevec. Students express a Gleevec‐resistant mutant of the Abelson tyrosine kinase domain, the active domain of an oncogenic ...
Taylor, Elizabeth Vogel +2 more
openaire +4 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Exploiting acquired vulnerability to develop novel treatments for cholangiocarcinoma
Cancer Cell InternationalCholangiocarcinoma (CCA) presents a formidable therapeutic challenge due to its extensive heterogeneity and plasticity, which inevitably lead to acquired resistance to current treatments. However, recent evidence suggests that acquired drug resistance is
Sirayot Areewong +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Chromosomal instability and acquired drug resistance in multiple myeloma
Oncotarget, 2017 Chromosomal instability (CIN) is an important hallmark of human cancer. CIN not only contributes to all stages of tumor development (initiation, promotion and progression) but also drives, in large measure, the acquisition of drug resistance by cancer cells.
Wang, Wang +7 more
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Acquired resistance to drugs targeting receptor tyrosine kinases [PDF]
Biochemical Pharmacology, 2012 Development of resistance to chemotherapeutic drugs represents a significant hindrance to the effective treatment of cancer patients. The molecular mechanisms responsible have been investigated for over half a century and have revealed the lack of a single cause.
openaire +2 more sources
Clinical Infectious Diseases, 2020 Abstract This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate.
Takashi Yoshiyama +6 more
openaire +2 more sources
Pharmacological modulation and manipulation of cancer drug resistance [PDF]
, 2010 The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
core +2 more sources
Lung India, 2009 Background/Aim: To study the prevalence and trend of acquired drug resistance to the first line antitubercular drugs . Materials and Methods: Sputum of 215 previously treated adult pulmonary tuberculosis (TB) patients over a period of 2002-2006 were ...
Rawat Jagdish, Sindhwani G, Dua Ruchi
doaj