Results 71 to 80 of about 4,548,181 (253)

Primary and acquired multidrug-resistant tuberculosis: Predictive factors for unfavorable treatment outcomes in Rio de Janeiro, 2000–2016

Revista Panamericana de Salud Pública, 2020
Objective. To identify clinical and demographic factors associated with unfavorable treatment outcomes in patients with primary and acquired multidrug-resistant tuberculosis (MDR-TB) in Rio de Janeiro State. Methods. Retrospective cohort study using data
Marcela Bhering, Afrânio Kritski
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira, Bansode Vijay, French Neil, Ngwira Bagrey, Crampin Amelia C, McCormack Grace P, Travers Simon A, Glynn Judith R, Shrestha Ram K   +29 more
core   +2 more sources

In situ modeling of acquired resistance to RTK/RAS-pathway-targeted therapies

iScience
Summary: Intrinsic and acquired resistance limit the window of effectiveness for oncogene-targeted cancer therapies. Here, we describe an in situ resistance assay (ISRA) that reliably models acquired resistance to RTK/RAS-pathway-targeted therapies ...
Nancy E. Sealover, Patricia T. Theard, Jacob M. Hughes, Amanda J. Linke, Brianna R. Daley, Robert L. Kortum   +5 more
doaj   +1 more source

Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase

Cell Reports, 2015
Protein kinases are therapeutic targets for human cancer. However, “gatekeeper” mutations in tyrosine kinases cause acquired clinical resistance, limiting long-term treatment benefits. mTOR is a key cancer driver and drug target.
Tzung-Ju Wu, Xiaowen Wang, Yanjie Zhang, Linghua Meng, John E. Kerrigan, Stephen K. Burley, X.F. Steven Zheng   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance [PDF]

, 2008
Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Nagasuma Chandra, Karthik Raman
core  

Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]

, 2010
BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim, Bloland, Peter, Malisa, Allen L, Roper, Cally, Allen L Malisa, Salim Abdulla, Cally Roper, Patrick S Kachur, Peter Bloland, Hassan Mshinda, Kachur, Patrick S, Richard J Pearce, Pearce, Richard J, Mshinda, Hassan   +13 more
core   +1 more source

The community-wide dilemma of hospital-acquired drug resistance [PDF]

Proceedings of the National Academy of Sciences, 2005
Few of us who even casually read the newspaper harbor the long-cherished belief that infectious diseases are a problem of the past. Infectious diseases, even during the most optimistic times, remained the major worldwide source of human mortality. At present ≈17–20 million people die annually of infectious diseases, mostly as a consequence of well ...
openaire   +2 more sources

Drug resistance and genetic transmission characteristics of HIV-1 CRF55_01B in people living with HIV/AIDS (PLWHA) in Henan Province, China

Retrovirology
Background Among the many CRFs, CRF55_01B was the first CRF01_AE and subtype B recombinant strain identified around 2013 among men who have sex with men (MSM) in Shenzhen, China.
Jie Ma, Jinjin Liu, Shuguang Wei, Mingjie Hou, Qingxia Zhao, Yuqi Huo   +5 more
doaj   +1 more source