Results 71 to 80 of about 380,265 (306)

Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area with high levels of drug resistance.

, 2007
BACKGROUND: Data on the performance of standardized short-course directly observed treatment (DOTS) of tuberculosis (TB) in areas with high levels of drug resistance and on the potential impact of DOTS on amplification of resistance are limited ...
Cox, H, J. D. Orozco, D. Doshetov, Blok, L, Kebede, Y, S. R. Gerdes, Y. Kebede, S. Niemann, Orozco, J D, Doshetov, D, Niemann, S, H. S. Cox, Rüsch-Gerdes, S, G. Ismailov, Ismailov, G, L. Blok   +15 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review

Frontiers in Oncology, 2023
Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable ...
Xian-Wen Liang, Bing- Liu, Jia-Cheng Chen, Zhi Cao, Feng-ran Chu, Xiong Lin, Sheng-Zhong Wang, Jin-Cai Wu   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Identification of a Non-Gatekeeper Hot Spot for Drug-Resistant Mutations in mTOR Kinase

Cell Reports, 2015
Protein kinases are therapeutic targets for human cancer. However, “gatekeeper” mutations in tyrosine kinases cause acquired clinical resistance, limiting long-term treatment benefits. mTOR is a key cancer driver and drug target.
Tzung-Ju Wu, Xiaowen Wang, Yanjie Zhang, Linghua Meng, John E. Kerrigan, Stephen K. Burley, X.F. Steven Zheng   +6 more
doaj   +1 more source

Primary and acquired multidrug-resistant tuberculosis: Predictive factors for unfavorable treatment outcomes in Rio de Janeiro, 2000–2016

Revista Panamericana de Salud Pública, 2020
Objective. To identify clinical and demographic factors associated with unfavorable treatment outcomes in patients with primary and acquired multidrug-resistant tuberculosis (MDR-TB) in Rio de Janeiro State. Methods. Retrospective cohort study using data
Marcela Bhering, Afrânio Kritski
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

In situ modeling of acquired resistance to RTK/RAS-pathway-targeted therapies

iScience
Summary: Intrinsic and acquired resistance limit the window of effectiveness for oncogene-targeted cancer therapies. Here, we describe an in situ resistance assay (ISRA) that reliably models acquired resistance to RTK/RAS-pathway-targeted therapies ...
Nancy E. Sealover, Patricia T. Theard, Jacob M. Hughes, Amanda J. Linke, Brianna R. Daley, Robert L. Kortum   +5 more
doaj   +1 more source

The community-wide dilemma of hospital-acquired drug resistance [PDF]

Proceedings of the National Academy of Sciences, 2005
Few of us who even casually read the newspaper harbor the long-cherished belief that infectious diseases are a problem of the past. Infectious diseases, even during the most optimistic times, remained the major worldwide source of human mortality. At present ≈17–20 million people die annually of infectious diseases, mostly as a consequence of well ...
openaire   +2 more sources

Pharmacological modulation and manipulation of cancer drug resistance [PDF]

, 2010
The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
core