Results 91 to 100 of about 4,548,181 (253)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Effect of immediate initiation of antiretroviral treatment on the risk of acquired HIV drug resistance [PDF]

, 2018
OBJECTIVE: We estimated and compared the risk of clinically identified acquired drug resistance under i) immediate initiation (the currently recommended ART initiation strategy), ii) initiation with CD4 
Lodi, S, Tracy R. Glass, Porter, Kholoud, Reiss, Peter, Phillips, Andrew N, Paraskevis, D, Georgia Vourli, Glass, Tracy R, Metallidis Simeon, Federico Garcia, Vourli, Georgia, Sophie Jose, Miguel A. Hernán, Glass, TR, Paraskevis, Dimitrios, Andrew N. Phillips, Logan, R, Jose, Sophie, Collaboration, The HIV-CAUSAL, Bucher, Heiner C, Sabin, Caroline, Boender, T Sonia, T. Sonia Boender, Dunn, David, Schneider, Marie-Paule, Egger, M, Boender, T. Sonia, Santiago Moreno, Matthias Egger, Günthard, Huldrych F., van Sighem, Ard, Lodi, Sara, Sabin, C, Marie-Paule Schneider, Kholoud Porter, Scherrer, Alexandra U, Günthard, HF, Bucher, HC, Garcia, Federico, Bucher, Heiner C., Dimitrios Paraskevis, Moreno, Santiago, Roger Logan, Peter Reiss, Egger, Matthias, Phillips, AN, Vourli, G, Günthard, Huldrych F, Monge, Susana, Alexandra U. Scherrer, Porter, K, Monge, S, Hernán, Miguel A., HIV-CAUSAL Collaboration, ., David Dunn, Scherrer, Alexandra U., Sabin, Caroline; https://orcid.org/, Simeon, Metallidis, Glass, Tracy R., Heiner C. Bucher, Garcia, F, Schneider, M-P, David Hawkins, Boender, TS, Caroline Sabin, Huldrych F. Günthard, Scherrer, AU, Hawkins, D, Hernán, Miguel A, Ard van Sighem, Hawkins, David, Günthard, Huldrych F; https://orcid.org/, Reiss, P, Dunn, D, Moreno, S, Jose, S, Logan, Roger, Simeon, M, Phillips, Andrew N., HIV-CAUSAL Collaboration*, Susana Monge, Hernán, MA, Sara Lodi, van Sighem, A   +83 more
core   +3 more sources

Therapeutic drug monitoring to prevent acquired drug resistance of fluoroquinolones in the treatment of tuberculosis [PDF]

European Respiratory Journal, 2017
Therapeutic drug monitoring of fluoroquinolones might prevent acquired XDR-TB http://ow.ly ...
Forsman, Lina Davies, Bruchfeld, Judith, Alffenaar, Jan-Willem C.   +2 more
openaire   +2 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Anti-tuberculosis drug resistance in strains of Mycobacterium tuberculosis isolated from patients in a tertiary hospital in Bahia

Brazilian Journal of Infectious Diseases
Anti-tuberculosis drug resistance, particularly multiresistance, is a crucial issue in the control of tuberculosis (TB). This study estimated the prevalence of primary and acquired anti-tuberculosis drug resistance in strains of Mycobacterium ...
Eliana Dias Matos, Antônio Carlos Moreira Lemos, Carolina Bittencourt, Cristiane Leite Mesquita   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Modelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance. [PDF]

, 2007
BACKGROUND\ud \ud Intermittent preventive treatment (IPT) is a promising intervention for malaria control, although there are concerns about its impact on drug resistance.\ud \ud METHODS\ud \ud The key model inputs are age-specific values for a) baseline
Sutherland Colin, Schellenberg, David, Roper, C., Schellenberg, D., Roper Cally, Roper, Cally, Sutherland, C., Cissé, Badara, Alexander, N., Alexander Neal, Sutherland, Colin, Schellenberg David, Cissé Badara, Alexander, Neal   +13 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Post-translational modifications in drug resistance

Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits treatment effectiveness and cure rate of diseases. Protein post-translational modifications (PTMs) represented by glycosylation, ubiquitination, SUMOylation ...
Zhang, Cheng, Miao, Chenggui, Zhou, Xinyue, Chen, Zhe Sheng, Huang, Yurong, Wang, Bing, Song, Yingqiu, Feng, Yibin, Wu, Peng, Wang, Xiao   +9 more
core   +1 more source

The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]

, 2014
This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
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