Results 81 to 90 of about 380,265 (306)

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs [PDF]

, 2013
Objectives: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Lee, Rebecca S, Burchmore, Richard J S, Natto, Manal J, Eze, Anthonius, Graf, Fabrice, Burchmore, Richard JS, Lee, Rebecca, de Koning, Harry, Glover, Lucy, Mäser, Pascal, Teka, Ibrahim, Barrett, Michael P., Munday, Jane C., Teka, Ibrahim A., De Koning, Harry P., Eze, Anthonius A, Graf, Fabrice E., De Koning, Harry P, Ludin, Philipp, McDonald, Jennifer, MacLeod, Annette, Turner, C Michael R., Munday, Jane C, Natto, Manal J., Lee, Rebecca S., Tait, Andy, Horn, David, Baker, Nicola, Munday, Jane, Turner, C Michael R, Aguinaga Andres, David, Barrett, Michael P, Andrés, David Aguinaga, Burchmore, Richard, Clucas, Caroline, Graf, Fabrice E, Horn, David; id_orcid, Burchmore, Richard J. S., Teka, Ibrahim A, Eze, Anthonius A., Natto, Manal, Turner, C. Michael R., Barrett, Michael   +42 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Drug resistance and genetic transmission characteristics of HIV-1 CRF55_01B in people living with HIV/AIDS (PLWHA) in Henan Province, China

Retrovirology
Background Among the many CRFs, CRF55_01B was the first CRF01_AE and subtype B recombinant strain identified around 2013 among men who have sex with men (MSM) in Shenzhen, China.
Jie Ma, Jinjin Liu, Shuguang Wei, Mingjie Hou, Qingxia Zhao, Yuqi Huo   +5 more
doaj   +1 more source

Prevalence of acquired drug resistance mutations in antiretroviral- experiencing subjects from 2012 to 2017 in Hunan Province of central South China

Virology Journal, 2020
Background There are few data on the prevalence of acquired drug resistance mutations (ADRs) in Hunan Province, China, that could affect the effectiveness of antiretroviral therapy (ART). Objectives The main objectives of this study were to determine the
Xiaobai Zou, Jianmei He, Jun Zheng, Roberta Malmgren, Weisi Li, Xiuqing Wei, Guoqiang Zhang, Xi Chen   +7 more
doaj   +1 more source

Autocrine EGF and TGF‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer

Pharmacology Research & Perspectives, 2023
Drug resistance severely limits the clinical therapeutic value of molecularly targeted drugs. Growth factors gain a tremendous amount of focus due to the ability to promote drug resistance in non‐small‐cell lung cancer (NSCLC).
Yueqin Wang, Yu Zhang, Ruiying Chen, Xin Tian   +3 more
doaj   +1 more source

Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]

, 2010
Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prevalence of total, acquired and ART-adjusted HIV drug resistance.

, 2019
A: Prevalence of total drug resistance at 2018. B: Prevalence of total drug resistance by 2030. C: Prevalence of acquired drug resistance mutations by 2030. D: Prevalence of acquired drug-resistant mutants by 2030.
Yajun Ding (3126264), Gregory Hood (224388), Robert L. Glaubius (6912509), Ume L. Abbas (224384)   +3 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population

Stem Cell Reports, 2017
Taxanes are a mainstay of treatment for breast cancer, but resistance often develops followed by metastatic disease and mortality. Aiming to reveal the mechanisms underlying taxane resistance, we used breast cancer patient-derived orthoxenografts (PDX ...
Jorge Gómez-Miragaya, Marta Palafox, Laia Paré, Guillermo Yoldi, Irene Ferrer, Sergi Vila, Patricia Galván, Pasquale Pellegrini, Hector Pérez-Montoyo, Ana Igea, Purificación Muñoz, Manel Esteller, Angel R. Nebreda, Ander Urruticoechea, Idoia Morilla, Sonia Pernas, Fina Climent, María Teresa Soler-Monso, Ana Petit, Violeta Serra, Aleix Prat, Eva González-Suárez   +21 more
doaj   +1 more source