Results 111 to 120 of about 370,457 (256)

Pre-treatment and acquired HIV drug resistance in Hunan: a cross-sectional analysis of a growing challenge

BMC Infectious Diseases
Background HIV Drug Resistance (HIVDR) is a key consideration when determining ART regimens. In recent years, Pre-treatment Drug Resistance (PDR) and Acquired Drug Resistance (ADR) have been changing rapidly.
Shujing Long, Run Yao, Yumei Tang, Chengcheng Yu, Wei Tang, Jing Cao, Yaxiong Huang, Xinlan Lu, Sai Li, Rangjiao Liu, Lizhong Dai, Yan Huang, Fang Zheng   +12 more
doaj   +1 more source

An epigenetic mechanism of azole tolerance facilitates acquired antifungal resistance in Aspergillus fumigatus

mBio
Antibiotic tolerance paves the way for acquired resistance in bacterial pathogens. However, the mechanisms of tolerance and its evolutionary role in acquired resistance in pathogenic fungi, and particularly in filamentous fungi, remain elusive.
Sandeep Vellanki, Nathan DeMichaelis, Catherine Liao, Jason E. Stajich, Robert A. Cramer   +4 more
doaj   +1 more source

Low Prevalence of Pre-Treatment and Acquired Drug Resistance to Dolutegravir among Treatment Naïve Individuals Initiating on Tenofovir, Lamivudine and Dolutegravir in Zimbabwe. [PDF]

Viruses, 2023
Kouamou V, Washaya T, Ndhlovu CE, Manasa J.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress. [PDF]

Cell Mol Biol Lett, 2022
Catapano J, Luty M, Wróbel T, Pudełek M, Piwowarczyk K, Kędracka-Krok S, Siedlar M, Madeja Z, Czyż J.   +8 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Large cell neuroendocrine carcinoma transformation: A novel acquired drug resistance mechanism in colorectal adenocarcinoma. [PDF]

Cancer Innov, 2023
Du F, Han Y, Hu X, Xiao Y, Shi Y, Sun J, Sun Z, Yang Y, Yu J, Zhang X, Jia J.   +10 more
europepmc   +1 more source

Genetic Basis of Acquired Drug Resistance [PDF]

Public Health Reports (1896-1970), 1955
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source