Results 111 to 120 of about 380,265 (306)

ACT Now or Later: The Economics of Malaria Resistance [PDF]

In the past, malaria control efforts in sub-Saharan Africa have relied on a combination of vector control and effective treatment using chloroquine. With increasing resistance to chloroquine, attention has now turned to alternative treatment strategies ...
Laxminarayan, Ramanan
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Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol [PDF]

, 2013
The predominant mechanism of drug resistance in African trypanosomes is decreased drug uptake due to loss-of-function mutations in the genes for the transporters that mediate drug import. The role of transporters as determinants of drug susceptibility is
Kaiser Marcel, Brun Reto, de Koning Harry P., Patient Pati Pyana, Philippe Büscher, Büscher Philippe, Marcel Kaiser (41510), Mäser, Pascal, Ludin Philipp, Kaiser, Marcel, Büscher, Philippe, Harry P. de Koning (370318), Philipp Ludin, Pascal Mäser (87895), Philipp Ludin (228110), Horn David, Wenzler, Tanja, Tanja Wenzler, Patient Pati Pyana (224071), Graf, Fabrice E., David Horn, Ludin, Philipp, Marcel Kaiser, Pascal Mäser, Pyana, Patient Pati, Horn, David, David Horn (24969), Fabrice E. Graf (469055), Pyana Patient Pati, Philippe Büscher (150731), Fabrice E Graf, Wenzler Tanja, Tanja Wenzler (320253), Horn, David; id_orcid, Brun, Reto, Harry P de Koning, Graf Fabrice E., de Koning, Harry P., Reto Brun, Mäser Pascal, Reto Brun (41511)   +40 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus

, 2014
This work was supported by a grant from the U.S. Public Health Service 2 RO1 AI457838-14 and by grant UL1 TR000043-07S1 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational ...
Kim, Choonkeun, Hermínia de Lencastre, Matthew T. J. Holden, Holden, Matthew T J, María Pardos de la Gándara, Tomasz, Alexander, Parkhill, Julian, de Lencastre, Hermínia, Alexander Tomasz, Stephen D. Bentley, Janina Dordel, Dordel, Janina, Pardos de la Gándara, María, Chung, Marilyn, Bentley, Stephen D, Marilyn Chung, Choonkeun Kim, Julian Parkhill   +17 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Acquired HIV-1 drug resistance to reverse transcriptase and protease inhibitors among people failing antiretroviral therapy in Cameroon and implications for future treatment options

AIDS Research and Therapy
HIV-1 drug resistance (HIVDR) surveillance among individuals failing antiretroviral therapy (ART) is essential to selecting optimal ART-combinations for use in a public health approach in low-middle-income countries (LMICs) where routine HIVDR-testing ...
Joseph Fokam, Tekoh Tatiana Anim-Keng, Benjamin Thumamo Pokam, Collins Ambe Chenwi, Aude Christelle Ka’e, Ezechiel Ngoufack Jagni Semengue, Odile Estelle Grâce Beloumou Angong, Desire Takou, Alex Durand Nka, Sandrine Djupsa, Naomi-Karell Etame, Evariste Molimbou, Rogers Ajeh, Anne-Cecile Z-K Bissek, Vittorio Colizzi, Carlo-Federico Perno, Gregory-Edie Halle-Ekane, Nicaise Ndembi, Alexis Ndjolo   +18 more
doaj   +1 more source

Profile of drug-resistant tuberculosis in Western Maharashtra

Journal of Family Medicine and Primary Care, 2017
Context: Drug-resistant tuberculosis (TB) strains have evolved mainly due to incomplete or improper treatment of TB patients and are one of the hurdles in controlling TB problem.
Sudhakar W More, Malangori Abdulgani Parande, Sanjeev W Kamble, Manjunath S Kamble   +3 more
doaj   +1 more source

Inaccuracy of routine susceptibility tests for detection of erythromycin resistance of Campylobacter jejuni and Campylobacter coli

, 2009
In The Netherlands, both an increase in and regional differences in erythromycin resistance of Campylobacter jejuni and Campylobacter coli have been reported.
Claas, E.C.J., Dep Infectieziekten Immunologie, Beek, M.T., Advances in Veterinary Medicine, E.J. Kuijper, Mevius, D.J., van der Beek, M., Claas, E.C., Pelt, W., van, Pelt, W. van, E.C.J. Claas, D.J. Mevius, Wagenaar, J.A., van Pelt, W., M.T. van der Beek, Beek, M.T. van der, Kuijper, E.J., van der Beek, M.T., W. van Pelt, J.A. Wagenaar   +19 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Investigation of the role of LRP in multidrug resistance [PDF]

, 1998
There have been many reports linking the overexpression of the lung resistance-related protein (LRP) with cross-resistance to chemotherapeutic drugs.
Byrne, Daragh
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