Results 31 to 40 of about 380,265 (306)

Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis

Emerging Infectious Diseases, 2015
Rates and risk factors for acquired drug resistance and association with outcomes among patients with multidrug-resistant tuberculosis (MDR TB) are not well defined.
Russell R. Kempker, Maia Kipiani, Veriko Mirtskhulava, Nestani Tukvadze, Matthew J. Magee, Henry M. Blumberg   +5 more
doaj   +1 more source

Cancer Cells Acquire Resistance to Anticancer Drugs: An Update

Biomedical Journal, 2012
The efficacy of cancer chemotherapy is often affected by the emergence of resistant can-cer cells. While biochemical and pharmaco-logical mechanisms have been proposed to ex-plain chemo-resistance, the genes involved in this process have not been fully identified.
Hsing-Pang Lu, Chuck C.K Chao
openaire   +3 more sources

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential [PDF]

Cell, 2018
BRAF(V600E) mutant melanomas treated with inhibitors of the BRAF and MEK kinases almost invariably develop resistance that is frequently caused by reactivation of the mitogen activated protein kinase (MAPK) pathway. To identify novel treatment options for such patients, we searched for acquired vulnerabilities of MAPK inhibitor-resistant melanomas.
Wang, Liqin, Leite de Oliveira, Rodrigo, Huijberts, Sanne, Bosdriesz, Evert, Pencheva, Nora, Brunen, Diede, Bosma, Astrid, Song, Ji-Ying, Zevenhoven, John, Los-de Vries, G Tjitske, Horlings, Hugo, Nuijen, Bastiaan, Beijnen, Jos H, Schellens, Jan H M, Bernards, Rene   +14 more
openaire   +3 more sources

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira   +21 more
core   +1 more source

Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations

Viruses, 2020
Introduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug ...
Marta Pingarilho, Victor Pimentel, Isabel Diogo, Sandra Fernandes, Mafalda Miranda, Andrea Pineda-Pena, Pieter Libin, Kristof Theys, M. Rosário O. Martins, Anne-Mieke Vandamme, Ricardo Camacho, Perpétua Gomes, Ana Abecasis, on behalf of the Portuguese HIV-1 Resistance Study Group   +13 more
doaj   +1 more source

Spontaneous mutational patterns and novel mutations for bedaquiline and clofazimine resistance in Mycobacterium tuberculosis

Microbiology Spectrum, 2023
The 2022 World Health Organization guidelines recommend use of two core anti-tuberculosis (TB) drugs, bedaquiline (BDQ) and clofazimine (CFZ), for treatment of drug-resistant (DR)-TB.
Jin Shi, Yuanyuan Liu, Tuoya Wu, Lu Li, Shujing Han, Xiao Peng, Yuanyuan Shang, Yongli Guo, Yu Pang, Mengqiu Gao, Jie Lu   +10 more
doaj   +1 more source

Application of Basic Pharmacology and Dispensing Practice of Antibiotics in Accredited Drug-Dispensing Outlets in Tanzania. [PDF]

, 2013
Provision of pharmaceutical services in accredited drug-dispensing outlets (ADDOs) in Tanzania has not been reported. This study compared the antibiotics dispensing practice between ADDOs and part II shops, or duka la dawa baridi (DLDBs), in Tanzania ...
Minzi, O. M., Manyilizu, Vs, Manyilizu, V. S., Minzi, Om   +3 more
core   +1 more source

miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]

, 2012
Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Oak, Prajakta S., Prajakta S. Oak (115995), Florian Kopp, Andreas Roidl, Kopp, Florian, Roidl, Andreas, Prajakta S Oak, Florian Kopp (115988), Ernst Wagner (60760), Andreas Roidl (116002), Wagner, Ernst, Ernst Wagner   +11 more
core   +1 more source

Community-Acquired Pneumonia with Risk for Drug-Resistant Pathogens [PDF]

Southern Medical Journal, 2013
Pneumonia is a leading infectious cause of morbidity and mortality in the United States. The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have published treatment guidelines for community-acquired pneumonia (CAP) based upon the site of acquisition and specific pathogen risk.
Virginia, Fleming, Brian, Buck, Nancy, Nix, Parag, Kumar, Robin, Southwood   +4 more
openaire   +2 more sources

Effect of immediate initiation of antiretroviral treatment on the risk of acquired HIV drug resistance [PDF]

, 2018
OBJECTIVE: We estimated and compared the risk of clinically identified acquired drug resistance under i) immediate initiation (the currently recommended ART initiation strategy), ii) initiation with CD4 
Lodi, S, Tracy R. Glass, Porter, Kholoud, Reiss, Peter, Phillips, Andrew N, Paraskevis, D, Georgia Vourli, Glass, Tracy R, Metallidis Simeon, Federico Garcia, Vourli, Georgia, Sophie Jose, Miguel A. Hernán, Glass, TR, Paraskevis, Dimitrios, Andrew N. Phillips, Logan, R, Jose, Sophie, Collaboration, The HIV-CAUSAL, Bucher, Heiner C, Sabin, Caroline, Boender, T Sonia, T. Sonia Boender, Dunn, David, Schneider, Marie-Paule, Egger, M, Boender, T. Sonia, Santiago Moreno, Matthias Egger, Günthard, Huldrych F., van Sighem, Ard, Lodi, Sara, Sabin, C, Marie-Paule Schneider, Kholoud Porter, Scherrer, Alexandra U, Günthard, HF, Bucher, HC, Garcia, Federico, Bucher, Heiner C., Dimitrios Paraskevis, Moreno, Santiago, Roger Logan, Peter Reiss, Egger, Matthias, Phillips, AN, Vourli, G, Günthard, Huldrych F, Monge, Susana, Alexandra U. Scherrer, Porter, K, Monge, S, Hernán, Miguel A., HIV-CAUSAL Collaboration, ., David Dunn, Scherrer, Alexandra U., Sabin, Caroline; https://orcid.org/, Simeon, Metallidis, Glass, Tracy R., Heiner C. Bucher, Garcia, F, Schneider, M-P, David Hawkins, Boender, TS, Caroline Sabin, Huldrych F. Günthard, Scherrer, AU, Hawkins, D, Hernán, Miguel A, Ard van Sighem, Hawkins, David, Günthard, Huldrych F; https://orcid.org/, Reiss, P, Dunn, D, Moreno, S, Jose, S, Logan, Roger, Simeon, M, Phillips, Andrew N., HIV-CAUSAL Collaboration*, Susana Monge, Hernán, MA, Sara Lodi, van Sighem, A   +83 more
core   +1 more source