Results 31 to 40 of about 370,457 (256)
Extensive Drug Resistance Acquired During Treatment of Multidrug-Resistant Tuberculosis [PDF]
Clinical Infectious Diseases, 2014 Increasing access to drugs for the treatment of multidrug-resistant (MDR) tuberculosis is crucial but could lead to increasing resistance to these same drugs. In 2000, the international Green Light Committee (GLC) initiative began to increase access while attempting to prevent acquired resistance.To assess the GLC's impact, we followed adults with ...
J. Peter Cegielski +80 more
openaire +3 more sources
An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China.
PLoS ONE, 2017 BackgroundUnderstanding the mechanisms of drug resistance can facilitate better management of antiretroviral therapy, helping to prevent transmission and decrease the morbidity and mortality of people living with HIV/AIDS.
Fengdi Zhang +4 more
doaj +1 more source
Acquired Resistance to Drugs Targeting Tyrosine Kinases [PDF]
, 2018 Resistance to chemotherapeutic drugs exemplifies the greatest hindrance to effective treatment of cancer patients. The molecular mechanisms responsible have been investigated for over 50 years and have revealed the lack of a single cause, but instead, multiple mechanisms including induced expression of membrane transporters that pump drugs out of cells
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna +16 more
wiley +1 more source
Evolution of Acquired Drug Resistance in BRAF-Mutant Melanoma
DNAMelanoma is a highly aggressive type of skin cancer. Metastatic melanoma tumors have historically featured a particularly poor prognosis and have often been considered incurable.
Josué Ballesteros-Álvarez +1 more
doaj +1 more source
Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy. [PDF]
PLoS Computational Biology, 2015 Acquired resistance is one of the major barriers to successful cancer therapy. The development of resistance is commonly attributed to genetic heterogeneity. However, heterogeneity of drug penetration of the tumor microenvironment both on the microscopic
Feng Fu +2 more
doaj +1 more source
Acquired Drug Resistance: We Can Do More Than We Think! [PDF]
Clinical Infectious Diseases, 2014 Item does not contain ...
Alffenaar, J.W.C. +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Pharmaceuticals(1) Background: The objective of this study was to investigate the prevalence of genetic diversity and drug resistance mutations among people living with HIV (PLWH) attending clinics in Beijing. (2) Methods: A retrospective analysis was conducted on PLWH
Yan-Ze Shi +10 more
doaj +1 more source
A research‐inspired laboratory sequence investigating acquired drug resistance [PDF]
Biochemistry and Molecular Biology Education, 2010 AbstractHere, we present a six‐session laboratory exercise designed to introduce students to standard biochemical techniques in the context of investigating a high impact research topic, acquired resistance to the cancer drug Gleevec. Students express a Gleevec‐resistant mutant of the Abelson tyrosine kinase domain, the active domain of an oncogenic ...
Taylor, Elizabeth Vogel +2 more
openaire +4 more sources