Results 31 to 40 of about 4,548,181 (253)

Next generation systemic acquired resistance [PDF]

, 2011
Systemic acquired resistance (SAR) is a plant immune response to pathogen attack. Recent evidence suggests that plant immunity involves regulation by chromatin remodeling and DNA methylation.
Luna Diez, Estrella, Victor Flors, Roberts, M. R., Toby J.A. Bruce, Bruce, T. J. A., Roberts, Michael, Jurriaan Ton, Luna, E., Flors, V., Ton, Jurriaan, Luna, Estrella, Estrella Luna, Flors, Victor, Bruce, Toby, Michael R. Roberts, Bruce, Toby J. A., Ton, J.   +16 more
core   +2 more sources

Cancer Cells Acquire Resistance to Anticancer Drugs: An Update

Biomedical Journal, 2012
The efficacy of cancer chemotherapy is often affected by the emergence of resistant can-cer cells. While biochemical and pharmaco-logical mechanisms have been proposed to ex-plain chemo-resistance, the genes involved in this process have not been fully identified.
Hsing-Pang Lu, Chuck C.K Chao
openaire   +3 more sources

Spontaneous mutational patterns and novel mutations for bedaquiline and clofazimine resistance in Mycobacterium tuberculosis

Microbiology Spectrum, 2023
The 2022 World Health Organization guidelines recommend use of two core anti-tuberculosis (TB) drugs, bedaquiline (BDQ) and clofazimine (CFZ), for treatment of drug-resistant (DR)-TB.
Jin Shi, Yuanyuan Liu, Tuoya Wu, Lu Li, Shujing Han, Xiao Peng, Yuanyuan Shang, Yongli Guo, Yu Pang, Mengqiu Gao, Jie Lu   +10 more
doaj   +1 more source

Community-Acquired Pneumonia with Risk for Drug-Resistant Pathogens [PDF]

Southern Medical Journal, 2013
Pneumonia is a leading infectious cause of morbidity and mortality in the United States. The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have published treatment guidelines for community-acquired pneumonia (CAP) based upon the site of acquisition and specific pathogen risk.
Virginia, Fleming, Brian, Buck, Nancy, Nix, Parag, Kumar, Robin, Southwood   +4 more
openaire   +2 more sources

Role of STAT3 in Resistance of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2019
The inflammatory state of tumor microenvironment play an important role in non-small cell lung cancer (NSCLC) drug resistance. As the key signal pathway connecting inflammation and tumor, activated signal transduction and transcriptional activation ...
Sibo SUN, Shidai JIN, Renhua GUO
doaj   +1 more source

Prevalence and trends in transmitted and acquired antiretroviral drug resistance, Washington, DC, 1999–2014

BMC Research Notes, 2017
Background Drug resistance limits options for antiretroviral therapy (ART) and results in poorer health outcomes among HIV-infected persons. We sought to characterize resistance patterns and to identify predictors of resistance in Washington, DC. Methods
Annette M. Aldous, Amanda D. Castel, David M. Parenti, the DC Cohort Executive Committee   +3 more
doaj   +1 more source

Extensive Drug Resistance Acquired During Treatment of Multidrug-Resistant Tuberculosis [PDF]

Clinical Infectious Diseases, 2014
Increasing access to drugs for the treatment of multidrug-resistant (MDR) tuberculosis is crucial but could lead to increasing resistance to these same drugs. In 2000, the international Green Light Committee (GLC) initiative began to increase access while attempting to prevent acquired resistance.To assess the GLC's impact, we followed adults with ...
J. Peter Cegielski, Tracy Dalton, Martin Yagui, Wanpen Wattanaamornkiet, Grigory V. Volchenkov, Laura E. Via, Martie Van Der Walt, Thelma Tupasi, Sarah E. Smith, Ronel Odendaal, Vaira Leimane, Charlotte Kvasnovsky, Tatiana Kuznetsova, Ekaterina Kurbatova, Tiina Kummik, Liga Kuksa, Kai Kliiman, Elena V. Kiryanova, HeeJin Kim, Chang-ki Kim, Boris Y. Kazennyy, Ruwen Jou, Wei-Lun Huang, Julia Ershova, Vladislav V. Erokhin, Lois Diem, Carmen Contreras, Sang Nae Cho, Larisa N. Chernousova, Michael P. Chen, Janice Campos Caoili, Jaime Bayona, Somsak Akksilp, Gloria Yale Calahuanca, Melanie Wolfgang, Piret Viiklepp, Irina A. Vasilieva, Allison Taylor, Kathrine Tan, Carmen Suarez, Ingrida Sture, Tatiana Somova, Tatyana G. Smirnova, Erika Sigman, Girts Skenders, Wanlaya Sitti, Isdore C. Shamputa, Vija Riekstina, Kristine Rose Pua, M. Therese, C. Perez, Seungkyu Park, Inga Norvaisha, Evgenia S. Nemtsova, Seonyeong Min, Beverly Metchock, Klavdia Levina, Yung-Chao Lei, Jongseok Lee, Elena E. Larionova, Joey Lancaster, Doosoo Jeon, Oswaldo Jave, Tatiana Khorosheva, Soo Hee Hwang, Angela Song-En Huang, M. Tarcela Gler, Gunta Dravniece, Seokyong Eum, Olga V. Demikhova, Irina Degtyareva, Manfred Danilovits, Anda Cirula, Eunjin Cho, Ying Cai, Jeanette Brand, Cesar Bonilla, Clifton E. Barry, Luis Asencios, Sofia N. Andreevskaya, Rattanawadee Akksilp   +80 more
openaire   +3 more sources

Polo like kinase 2 tumour suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer [PDF]

, 2012
The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers. The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian ...
Mcneish, I., Blagden, S., Hatzimichael, E., Syed, N., Coley, H.M., Crook, T., Thompson, A.   +6 more
core   +6 more sources

An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China.

PLoS ONE, 2017
BackgroundUnderstanding the mechanisms of drug resistance can facilitate better management of antiretroviral therapy, helping to prevent transmission and decrease the morbidity and mortality of people living with HIV/AIDS.
Fengdi Zhang, Li Liu, Meiyan Sun, Jianjun Sun, Hongzhou Lu   +4 more
doaj   +1 more source

The Integration of Proteomics and Metabolomics Data Paving the Way for a Better Understanding of the Mechanisms Underlying Microbial Acquired Drug Resistance

Frontiers in Medicine, 2022
Due to an increase in the overuse of antimicrobials and accelerated incidence of drug resistant pathogens, antimicrobial resistance has become a global health threat.
Suereta Fortuin, Nelson C. Soares, Nelson C. Soares   +2 more
doaj   +1 more source