Results 21 to 30 of about 380,265 (306)

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S   +20 more
core   +1 more source

Risk Factors for Acquisition of Drug Resistance during Multidrug-Resistant Tuberculosis Treatment, Arkhangelsk Oblast, Russia, 2005–2010

Emerging Infectious Diseases, 2015
Acquired resistance to antituberculosis drugs decreases effective treatment options and the likelihood of treatment success. We identified risk factors for acquisition of drug resistance during treatment for multidrug-resistant tuberculosis (MDR TB) and ...
Sarah E. Smith, Julia Ershova, Natalia Vlasova, Elena Nikishova, Irina Tarasova, Platon Eliseev, Andrey Maryandyshev, Igor G. Shemyakin, Ekaterina V. Kurbatova, J. Peter Cegielski   +9 more
doaj   +1 more source

Acquired Resistance Is Oncogene and Drug Agnostic [PDF]

Cancer Cell, 2019
Recent approvals of TRK inhibitors have demonstrated the success of a tumor agnostic approach to oncogene-targeted therapy across cancers. Collective data from acquired resistance studies suggest that resistance mechanisms, which include both kinase domain mutations and bypass signaling via RTK-RAS-RAF-MAPK pathways, frequently recur regardless of ...
openaire   +2 more sources

Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei [PDF]

, 2016
Objectives The objective of this study was to identify the mechanisms of resistance to nifurtimox and fexinidazole in African trypanosomes. Methods Bloodstream-form Trypanosoma brucei were selected for resistance to nifurtimox and fexinidazole by ...
Kelner, Anna, Fairlamb, Alan; id_orcid, Berriman, Matthew, Foth, Bernado J., Sokolova, Antoaneta Y., Wyllie, Susan   +5 more
core   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M., Teodoridis, JM, Glasspool, RM, Teodoridis, J.M., Brown, R, R M Glasspool, Brown, R., J M Teodoridis, R Brown   +8 more
core   +1 more source

Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa. [PDF]

, 2014
In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and
Martin Antonio, Odin Goovaerts (138054), Martin Gninafon, Lingoupou, Fanny M, Elie Nduwamahoro (672710), Juergen Noeske (672717), Alberto Piubello (672716), Ba, Fatoumata, Cécile Uwizeye (5661748), Elie Nduwamahoro, Martin Antonio (42317), Gehre, Florian, Oumou Sow (672713), Sow, Oumou, Dissou Affolabi (470788), Kristina Fissette (672709), Gninafon, Martin, Bouke C de Jong, Sarr, Marie, Dissou Affolabi, Uwizeye, Cécile, Alberto Piubello, Mebrat Ejo, Ejo, Mebrat, de Rijk, Pim, Fanny M Lingoupou, Kristina Fissette, Merle, Corinne, Leen Rigouts (62768), Nduwamahoro, Elie, Odin Goovaerts, Mamadou Dian Barry, Barry, Mamadou Dian, Martin Gninafon (561425), Affolabi, Dissou, Goovaerts, Odin, Marie Sarr, Florian Gehre, Pim de Rijk (377868), Noeske, Juergen, Oumou Sow, Cécile Uwizeye, Fanny M. Lingoupou (672711), Piero Olliaro (35337), Fissette, Kristina, Piubello, Alberto, Corinne Merle, Florian Gehre (182718), Mamadou Dian Barry (672712), Marie Sarr (672715), Rigouts, Leen, Piero Olliaro, Fatoumata Ba, Corinne Merle (514025), Mebrat Ejo (672708), Juergen Noeske, Fatoumata Ba (672714), de Jong, Bouke C, Pim de Rijk, Bouke C de Jong (378876), Olliaro, Piero, Leen Rigouts, Antonio, Martin   +62 more
core   +1 more source

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance

Biomedicines, 2022
Acquired drug resistance represents a major clinical problem and one of the biggest limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using standard chemotherapeutic agents, together with bioactive natural compounds ...
Laura Ioana Gavrilas, Daniel Cruceriu, Andrei Mocan, Felicia Loghin, Doina Miere, Ovidiu Balacescu   +5 more
doaj   +1 more source

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H   +55 more
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Perturbations in 3D genome organization can promote acquired drug resistance

Cell Reports, 2023
Summary: Acquired drug resistance is a major problem in the treatment of cancer. hTERT-immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing the ABCB1 gene, encoding for the multidrug transporter P-gP.
Anna G. Manjón, Stefano Giustino Manzo, Stefan Prekovic, Leon Potgeter, Tom van Schaik, Ning Qing Liu, Koen Flach, Daniel Peric-Hupkes, Stacey Joosten, Hans Teunissen, Anoek Friskes, Mila Ilic, Dorine Hintzen, Vinícius H. Franceschini-Santos, Wilbert Zwart, Elzo de Wit, Bas van Steensel, René H. Medema   +17 more
doaj   +1 more source