Results 21 to 30 of about 370,457 (256)

Plant-Derived Bioactive Compounds in Colorectal Cancer: Insights from Combined Regimens with Conventional Chemotherapy to Overcome Drug-Resistance

Biomedicines, 2022
Acquired drug resistance represents a major clinical problem and one of the biggest limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using standard chemotherapeutic agents, together with bioactive natural compounds ...
Laura Ioana Gavrilas, Daniel Cruceriu, Andrei Mocan, Felicia Loghin, Doina Miere, Ovidiu Balacescu   +5 more
doaj   +1 more source

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential [PDF]

Cell, 2018
BRAF(V600E) mutant melanomas treated with inhibitors of the BRAF and MEK kinases almost invariably develop resistance that is frequently caused by reactivation of the mitogen activated protein kinase (MAPK) pathway. To identify novel treatment options for such patients, we searched for acquired vulnerabilities of MAPK inhibitor-resistant melanomas.
Wang, Liqin, Leite de Oliveira, Rodrigo, Huijberts, Sanne, Bosdriesz, Evert, Pencheva, Nora, Brunen, Diede, Bosma, Astrid, Song, Ji-Ying, Zevenhoven, John, Los-de Vries, G Tjitske, Horlings, Hugo, Nuijen, Bastiaan, Beijnen, Jos H, Schellens, Jan H M, Bernards, Rene   +14 more
openaire   +3 more sources

Perturbations in 3D genome organization can promote acquired drug resistance

Cell Reports, 2023
Summary: Acquired drug resistance is a major problem in the treatment of cancer. hTERT-immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing the ABCB1 gene, encoding for the multidrug transporter P-gP.
Anna G. Manjón, Stefano Giustino Manzo, Stefan Prekovic, Leon Potgeter, Tom van Schaik, Ning Qing Liu, Koen Flach, Daniel Peric-Hupkes, Stacey Joosten, Hans Teunissen, Anoek Friskes, Mila Ilic, Dorine Hintzen, Vinícius H. Franceschini-Santos, Wilbert Zwart, Elzo de Wit, Bas van Steensel, René H. Medema   +17 more
doaj   +1 more source

Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis

Emerging Infectious Diseases, 2015
Rates and risk factors for acquired drug resistance and association with outcomes among patients with multidrug-resistant tuberculosis (MDR TB) are not well defined.
Russell R. Kempker, Maia Kipiani, Veriko Mirtskhulava, Nestani Tukvadze, Matthew J. Magee, Henry M. Blumberg   +5 more
doaj   +1 more source

Cancer Cells Acquire Resistance to Anticancer Drugs: An Update

Biomedical Journal, 2012
The efficacy of cancer chemotherapy is often affected by the emergence of resistant can-cer cells. While biochemical and pharmaco-logical mechanisms have been proposed to ex-plain chemo-resistance, the genes involved in this process have not been fully identified.
Hsing-Pang Lu, Chuck C.K Chao
openaire   +3 more sources

Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations

Viruses, 2020
Introduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug ...
Marta Pingarilho, Victor Pimentel, Isabel Diogo, Sandra Fernandes, Mafalda Miranda, Andrea Pineda-Pena, Pieter Libin, Kristof Theys, M. Rosário O. Martins, Anne-Mieke Vandamme, Ricardo Camacho, Perpétua Gomes, Ana Abecasis, on behalf of the Portuguese HIV-1 Resistance Study Group   +13 more
doaj   +1 more source

Spontaneous mutational patterns and novel mutations for bedaquiline and clofazimine resistance in Mycobacterium tuberculosis

Microbiology Spectrum, 2023
The 2022 World Health Organization guidelines recommend use of two core anti-tuberculosis (TB) drugs, bedaquiline (BDQ) and clofazimine (CFZ), for treatment of drug-resistant (DR)-TB.
Jin Shi, Yuanyuan Liu, Tuoya Wu, Lu Li, Shujing Han, Xiao Peng, Yuanyuan Shang, Yongli Guo, Yu Pang, Mengqiu Gao, Jie Lu   +10 more
doaj   +1 more source

Community-Acquired Pneumonia with Risk for Drug-Resistant Pathogens [PDF]

Southern Medical Journal, 2013
Pneumonia is a leading infectious cause of morbidity and mortality in the United States. The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have published treatment guidelines for community-acquired pneumonia (CAP) based upon the site of acquisition and specific pathogen risk.
Virginia, Fleming, Brian, Buck, Nancy, Nix, Parag, Kumar, Robin, Southwood   +4 more
openaire   +2 more sources

Role of STAT3 in Resistance of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2019
The inflammatory state of tumor microenvironment play an important role in non-small cell lung cancer (NSCLC) drug resistance. As the key signal pathway connecting inflammation and tumor, activated signal transduction and transcriptional activation ...
Sibo SUN, Shidai JIN, Renhua GUO
doaj   +1 more source

Prevalence and trends in transmitted and acquired antiretroviral drug resistance, Washington, DC, 1999–2014

BMC Research Notes, 2017
Background Drug resistance limits options for antiretroviral therapy (ART) and results in poorer health outcomes among HIV-infected persons. We sought to characterize resistance patterns and to identify predictors of resistance in Washington, DC. Methods
Annette M. Aldous, Amanda D. Castel, David M. Parenti, the DC Cohort Executive Committee   +3 more
doaj   +1 more source