Results 21 to 30 of about 4,548,181 (253)

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M., Teodoridis, JM, Glasspool, RM, Teodoridis, J.M., Brown, R, R M Glasspool, Brown, R., J M Teodoridis, R Brown   +8 more
core   +1 more source

Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa. [PDF]

, 2014
In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and
Martin Antonio, Odin Goovaerts (138054), Martin Gninafon, Lingoupou, Fanny M, Elie Nduwamahoro (672710), Juergen Noeske (672717), Alberto Piubello (672716), Ba, Fatoumata, Cécile Uwizeye (5661748), Elie Nduwamahoro, Martin Antonio (42317), Gehre, Florian, Oumou Sow (672713), Sow, Oumou, Dissou Affolabi (470788), Kristina Fissette (672709), Gninafon, Martin, Bouke C de Jong, Sarr, Marie, Dissou Affolabi, Uwizeye, Cécile, Alberto Piubello, Mebrat Ejo, Ejo, Mebrat, de Rijk, Pim, Fanny M Lingoupou, Kristina Fissette, Merle, Corinne, Leen Rigouts (62768), Nduwamahoro, Elie, Odin Goovaerts, Mamadou Dian Barry, Barry, Mamadou Dian, Martin Gninafon (561425), Affolabi, Dissou, Goovaerts, Odin, Marie Sarr, Florian Gehre, Pim de Rijk (377868), Noeske, Juergen, Oumou Sow, Cécile Uwizeye, Fanny M. Lingoupou (672711), Piero Olliaro (35337), Fissette, Kristina, Piubello, Alberto, Corinne Merle, Florian Gehre (182718), Mamadou Dian Barry (672712), Marie Sarr (672715), Rigouts, Leen, Piero Olliaro, Fatoumata Ba, Corinne Merle (514025), Mebrat Ejo (672708), Juergen Noeske, Fatoumata Ba (672714), de Jong, Bouke C, Pim de Rijk, Bouke C de Jong (378876), Olliaro, Piero, Leen Rigouts, Antonio, Martin   +62 more
core   +1 more source

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H, Happi, Christian, Zimmerman, Peter   +57 more
core   +1 more source

Drug resistance with monitored adherence [PDF]

, 2013
Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core   +1 more source

Acquired Drug Resistance in Mycobacterium tuberculosis and Poor Outcomes among Patients with Multidrug-Resistant Tuberculosis

Emerging Infectious Diseases, 2015
Rates and risk factors for acquired drug resistance and association with outcomes among patients with multidrug-resistant tuberculosis (MDR TB) are not well defined.
Russell R. Kempker, Maia Kipiani, Veriko Mirtskhulava, Nestani Tukvadze, Matthew J. Magee, Henry M. Blumberg   +5 more
doaj   +1 more source

Perturbations in 3D genome organization can promote acquired drug resistance

Cell Reports, 2023
Summary: Acquired drug resistance is a major problem in the treatment of cancer. hTERT-immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing the ABCB1 gene, encoding for the multidrug transporter P-gP.
Anna G. Manjón, Stefano Giustino Manzo, Stefan Prekovic, Leon Potgeter, Tom van Schaik, Ning Qing Liu, Koen Flach, Daniel Peric-Hupkes, Stacey Joosten, Hans Teunissen, Anoek Friskes, Mila Ilic, Dorine Hintzen, Vinícius H. Franceschini-Santos, Wilbert Zwart, Elzo de Wit, Bas van Steensel, René H. Medema   +17 more
doaj   +1 more source

Hsp90 governs dispersion and drug resistance of fungal biofilms [PDF]

, 2011
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of multiple cell types form on indwelling medical devices and their eradication often requires ...
Ramage Gordon, Lopez-Ribot, J.L., Rajendran Ranjith, Ramage, G., Leah E. Cowen, Uppuluri Priya, Robbins, N., Priya Uppuluri, Rajendran, R., Andes, D., Jose L Lopez-Ribot, David Andes, Leah E Cowen, Nicole Robbins, Uppuluri, P., Robbins Nicole, Nett Jeniel, Lopez-Ribot Jose L., Jose L. Lopez-Ribot, Cowen, L.E., Nett, J., Ranjith Rajendran, Gordon Ramage, Jeniel Nett, Andes David, Cowen Leah E.   +25 more
core   +2 more sources

An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential [PDF]

Cell, 2018
BRAF(V600E) mutant melanomas treated with inhibitors of the BRAF and MEK kinases almost invariably develop resistance that is frequently caused by reactivation of the mitogen activated protein kinase (MAPK) pathway. To identify novel treatment options for such patients, we searched for acquired vulnerabilities of MAPK inhibitor-resistant melanomas.
Wang, Liqin, Leite de Oliveira, Rodrigo, Huijberts, Sanne, Bosdriesz, Evert, Pencheva, Nora, Brunen, Diede, Bosma, Astrid, Song, Ji-Ying, Zevenhoven, John, Los-de Vries, G Tjitske, Horlings, Hugo, Nuijen, Bastiaan, Beijnen, Jos H, Schellens, Jan H M, Bernards, Rene   +14 more
openaire   +3 more sources

Increasing Prevalence of HIV-1 Transmitted Drug Resistance in Portugal: Implications for First Line Treatment Recommendations

Viruses, 2020
Introduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug ...
Marta Pingarilho, Victor Pimentel, Isabel Diogo, Sandra Fernandes, Mafalda Miranda, Andrea Pineda-Pena, Pieter Libin, Kristof Theys, M. Rosário O. Martins, Anne-Mieke Vandamme, Ricardo Camacho, Perpétua Gomes, Ana Abecasis, on behalf of the Portuguese HIV-1 Resistance Study Group   +13 more
doaj   +1 more source