Results 11 to 20 of about 380,265 (306)

Drug resistance in community-acquired respiratory tract infections: role for an emerging antibacterial

Infection and Drug Resistance, 2010
Lorenzo Aguilar1, María-José Giménez1, José Barberán21Microbiology Department, School of Medicine, University Complutense, Madrid; 2Infectious Diseases Department, Hospital Central de la Defensa ...
Lorenzo Aguilar, María-José Giménez, José Barberán   +2 more
doaj   +1 more source

Extensive Drug Resistance Acquired During Treatment of Multidrug-Resistant Tuberculosis [PDF]

Clinical Infectious Diseases, 2014
Increasing access to drugs for the treatment of multidrug-resistant (MDR) tuberculosis is crucial but could lead to increasing resistance to these same drugs. In 2000, the international Green Light Committee (GLC) initiative began to increase access while attempting to prevent acquired resistance.To assess the GLC's impact, we followed adults with ...
J. Peter Cegielski, Tracy Dalton, Martin Yagui, Wanpen Wattanaamornkiet, Grigory V. Volchenkov, Laura E. Via, Martie Van Der Walt, Thelma Tupasi, Sarah E. Smith, Ronel Odendaal, Vaira Leimane, Charlotte Kvasnovsky, Tatiana Kuznetsova, Ekaterina Kurbatova, Tiina Kummik, Liga Kuksa, Kai Kliiman, Elena V. Kiryanova, HeeJin Kim, Chang-ki Kim, Boris Y. Kazennyy, Ruwen Jou, Wei-Lun Huang, Julia Ershova, Vladislav V. Erokhin, Lois Diem, Carmen Contreras, Sang Nae Cho, Larisa N. Chernousova, Michael P. Chen, Janice Campos Caoili, Jaime Bayona, Somsak Akksilp, Gloria Yale Calahuanca, Melanie Wolfgang, Piret Viiklepp, Irina A. Vasilieva, Allison Taylor, Kathrine Tan, Carmen Suarez, Ingrida Sture, Tatiana Somova, Tatyana G. Smirnova, Erika Sigman, Girts Skenders, Wanlaya Sitti, Isdore C. Shamputa, Vija Riekstina, Kristine Rose Pua, M. Therese, C. Perez, Seungkyu Park, Inga Norvaisha, Evgenia S. Nemtsova, Seonyeong Min, Beverly Metchock, Klavdia Levina, Yung-Chao Lei, Jongseok Lee, Elena E. Larionova, Joey Lancaster, Doosoo Jeon, Oswaldo Jave, Tatiana Khorosheva, Soo Hee Hwang, Angela Song-En Huang, M. Tarcela Gler, Gunta Dravniece, Seokyong Eum, Olga V. Demikhova, Irina Degtyareva, Manfred Danilovits, Anda Cirula, Eunjin Cho, Ying Cai, Jeanette Brand, Cesar Bonilla, Clifton E. Barry, Luis Asencios, Sofia N. Andreevskaya, Rattanawadee Akksilp   +80 more
openaire   +4 more sources

Immune Disorders in Patients with Pulmonary Tuberculosis with Primary and Acquired Drug-Resistance of Mycobacterium Tuberculosis

Туберкулез и болезни лёгких, 2022
The objective: to evaluate main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological ...
E. Lesnik, S. Ginda
doaj   +1 more source

The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS

Antioxidants, 2021
The characteristics of phthalates had been thought to be similar to endocrine disruptors, which increases cancer risk. The role of phthalates in acquired drug resistance remains unclear.
Mahendra Jadhao, Eing-Mei Tsai, Ho-Chun Yang, Yih-Fung Chen, Shih-Shin Liang, Tsu-Nai Wang, Yen-Ni Teng, Hurng-Wern Huang, Li-Fang Wang, Chien-Chih Chiu   +9 more
doaj   +1 more source

Loss of MHC-I antigen presentation correlated with immune checkpoint blockade tolerance in MAPK inhibitor-resistant melanoma

Frontiers in Pharmacology, 2022
Immune checkpoint blockade and MAPK-targeted combined therapy is a promising regimen for advanced melanoma patients. However, the clinical benefit from this combo regimen remains limited, especially in patients who acquired resistance to MAPK-targeted ...
Jing Yu, Xi Wu, Jinen Song, Yujie Zhao, Huifang Li, Min Luo, Xiaowei Liu   +6 more
doaj   +1 more source

Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer

Frontiers in Pharmacology, 2021
Although chemotherapy, targeted therapy and endocrine therapy decrease rate of disease recurrence in most breast cancer patients, many patients exhibit acquired resistance.
Chao Dong, Jiao Wu, Yin Chen, Jianyun Nie, Ceshi Chen, Ceshi Chen   +5 more
doaj   +1 more source

Explaining risk factors for drug-resistant tuberculosis in England and Wales: contribution of primary and secondary drug resistance [PDF]

, 2004
Drug-resistant tuberculosis can be transmitted (primary) or develop during the course of treatment (secondary). We investigated risk factors for each type of resistance.
Glynn, JR, Story, A, Hayward, AC, Watson, JM, Conaty, SJ, Drobniewski, FA   +5 more
core   +1 more source

Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000–2015

Emerging Infectious Diseases, 2018
Among tuberculosis (TB) patients, acquired resistance to anti-TB drugs represents a failure in the treatment pathway. To improve diagnosis and care for patients with drug-resistant TB, we examined the epidemiology and risk factors associated with ...
Miranda G. Loutet, Jennifer A. Davidson, Tim Brown, Martin Dedicoat, H. Lucy Thomas, Maeve K. Lalor   +5 more
doaj   +1 more source

Clinical utility of PDX cohorts to reveal biomarkers of intrinsic resistance and clonal architecture changes underlying acquired resistance to cetuximab in HNSCC

Signal Transduction and Targeted Therapy, 2022
Cetuximab is a widely used drug for treating head and neck squamous cell carcinomas (HNSCCs); however, it provides restricted clinical benefits, and its response duration is limited by drug resistance.
Yanli Yao, Yujue Wang, Lan Chen, Zhen Tian, Guizhu Yang, Rui Wang, Chong Wang, Qi Wu, Yaping Wu, Jiamin Gao, Xindan Kang, Shengzhong Duan, Zhiyuan Zhang, Shuyang Sun   +13 more
doaj   +1 more source

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Naomi Walsh, Martin Clynes, Rizwan Sheikh, Sheikh, Rizwan, O'Connor, Robert A., Robert O’Connor, Ray McDermott, O'Connor, Robert, Clynes, Martin, Walsh, Naomi, McDermott, Ray   +10 more
core   +1 more source