Results 11 to 20 of about 370,457 (256)

Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019: A Comparison Between the Populations of Late Presenters and Non-late Presenters. [PDF]

Front Microbiol, 2022
Miranda MNS, Pingarilho M, Pimentel V, Martins MDRO, Kaiser R, Seguin-Devaux C, Paredes R, Zazzi M, Incardona F, Abecasis AB.   +9 more
europepmc   +2 more sources

EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance [PDF]

Cancers, 2021
The epidermal growth factor receptor (EGFR) has served as the founding member of the large family of growth factor receptors harboring intrinsic tyrosine kinase function. High abundance of EGFR and large internal deletions are frequently observed in brain tumors, whereas point mutations and small insertions within the kinase domain are common in lung ...
Uribe M. L., Marrocco I., Yarden Y.
openaire   +3 more sources

Immune Disorders in Patients with Pulmonary Tuberculosis with Primary and Acquired Drug-Resistance of Mycobacterium Tuberculosis

Туберкулез и болезни лёгких, 2022
The objective: to evaluate main parameters of cellular, humoral immunity and natural resistance in tuberculosis patients with primary and acquired multiple drug resistance; to study the correlation of these parameters with clinical and radiological ...
E. Lesnik, S. Ginda
doaj   +1 more source

The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS

Antioxidants, 2021
The characteristics of phthalates had been thought to be similar to endocrine disruptors, which increases cancer risk. The role of phthalates in acquired drug resistance remains unclear.
Mahendra Jadhao, Eing-Mei Tsai, Ho-Chun Yang, Yih-Fung Chen, Shih-Shin Liang, Tsu-Nai Wang, Yen-Ni Teng, Hurng-Wern Huang, Li-Fang Wang, Chien-Chih Chiu   +9 more
doaj   +1 more source

Loss of MHC-I antigen presentation correlated with immune checkpoint blockade tolerance in MAPK inhibitor-resistant melanoma

Frontiers in Pharmacology, 2022
Immune checkpoint blockade and MAPK-targeted combined therapy is a promising regimen for advanced melanoma patients. However, the clinical benefit from this combo regimen remains limited, especially in patients who acquired resistance to MAPK-targeted ...
Jing Yu, Xi Wu, Jinen Song, Yujie Zhao, Huifang Li, Min Luo, Xiaowei Liu   +6 more
doaj   +1 more source

Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer

Frontiers in Pharmacology, 2021
Although chemotherapy, targeted therapy and endocrine therapy decrease rate of disease recurrence in most breast cancer patients, many patients exhibit acquired resistance.
Chao Dong, Jiao Wu, Yin Chen, Jianyun Nie, Ceshi Chen, Ceshi Chen   +5 more
doaj   +1 more source

Clinical utility of PDX cohorts to reveal biomarkers of intrinsic resistance and clonal architecture changes underlying acquired resistance to cetuximab in HNSCC

Signal Transduction and Targeted Therapy, 2022
Cetuximab is a widely used drug for treating head and neck squamous cell carcinomas (HNSCCs); however, it provides restricted clinical benefits, and its response duration is limited by drug resistance.
Yanli Yao, Yujue Wang, Lan Chen, Zhen Tian, Guizhu Yang, Rui Wang, Chong Wang, Qi Wu, Yaping Wu, Jiamin Gao, Xindan Kang, Shengzhong Duan, Zhiyuan Zhang, Shuyang Sun   +13 more
doaj   +1 more source

Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000–2015

Emerging Infectious Diseases, 2018
Among tuberculosis (TB) patients, acquired resistance to anti-TB drugs represents a failure in the treatment pathway. To improve diagnosis and care for patients with drug-resistant TB, we examined the epidemiology and risk factors associated with ...
Miranda G. Loutet, Jennifer A. Davidson, Tim Brown, Martin Dedicoat, H. Lucy Thomas, Maeve K. Lalor   +5 more
doaj   +1 more source

Risk Factors for Acquisition of Drug Resistance during Multidrug-Resistant Tuberculosis Treatment, Arkhangelsk Oblast, Russia, 2005–2010

Emerging Infectious Diseases, 2015
Acquired resistance to antituberculosis drugs decreases effective treatment options and the likelihood of treatment success. We identified risk factors for acquisition of drug resistance during treatment for multidrug-resistant tuberculosis (MDR TB) and ...
Sarah E. Smith, Julia Ershova, Natalia Vlasova, Elena Nikishova, Irina Tarasova, Platon Eliseev, Andrey Maryandyshev, Igor G. Shemyakin, Ekaterina V. Kurbatova, J. Peter Cegielski   +9 more
doaj   +1 more source

Acquired Resistance Is Oncogene and Drug Agnostic [PDF]

Cancer Cell, 2019
Recent approvals of TRK inhibitors have demonstrated the success of a tumor agnostic approach to oncogene-targeted therapy across cancers. Collective data from acquired resistance studies suggest that resistance mechanisms, which include both kinase domain mutations and bypass signaling via RTK-RAS-RAF-MAPK pathways, frequently recur regardless of ...
openaire   +2 more sources