Results 51 to 60 of about 50,445 (343)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Spectral Energy of High-Speed Over-Expanded Nozzle Flows at Different Pressure Ratios

Energies
This paper addresses the long-standing question of understanding the origin and evolution of low-frequency unsteadiness interactions associated with shock waves impinging on a turbulent boundary layer in transonic flow (Mach: 1.1 to 1.3).
Manish Tripathi, Sławomir Dykas, Mirosław Majkut, Krystian Smołka, Kamil Skoczylas, Andrzej Boguslawski   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Manifold Learning for Aerodynamic Shape Design Optimization

Aerospace
The significant computational cost incurred due to the iterative nature of Computational Fluid Dynamics (CFD) in traditional aerodynamic shape design frameworks poses a major challenge, especially in the context of modern integrated design requirements ...
Boda Zheng, Abhijith Moni, Weigang Yao, Min Xu   +3 more
doaj   +1 more source

Study of separation phenomenon in transonic flows produced by interaction between shock wave and boundary layer

Vietnam Journal of Mechanics, 2011
For compressible flows, the transonic state depends on the geometry, Mach number and the incidence. This effect can produce shock wave. Some studies showed that the interaction between shock wave and boundary layer concerns separation phenomenon. Studies
Hoang Thi Bich Ngoc, Nguyen Manh Hung
doaj   +1 more source

Numerical Study of the Lift Enhancement Mechanism of Circulation Control in Transonic Flow

Aerospace, 2021
The lift of an aircraft can be effectively enhanced by circulation control (CC) technology at subsonic speeds, but the efficiency at transonic speeds is greatly decreased. The underlying mechanism of this phenomenon is not fully understood. In this study,
Ye Chen, Zhongxi Hou, Xiaolong Deng, Zheng Guo, Shuai Shao, Boting Xu   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Receptivity and Stability Theory Analysis of a Transonic Swept Wing Experiment

Aerospace, 2023
Surface suction provides an efficient way to delay boundary layer transitions. In order to verify the suction effects and determine the mechanism of suction control in transonic swept wing boundary layers, wind tunnel transition measurements in a hybrid ...
Yuanqiang Liu, Yan Liu, Zubi Ji, Yutian Wang, Jiakuan Xu   +4 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source