Results 51 to 60 of about 97,655 (378)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Numerical Study of the Lift Enhancement Mechanism of Circulation Control in Transonic Flow

Aerospace, 2021
The lift of an aircraft can be effectively enhanced by circulation control (CC) technology at subsonic speeds, but the efficiency at transonic speeds is greatly decreased. The underlying mechanism of this phenomenon is not fully understood. In this study,
Ye Chen, Zhongxi Hou, Xiaolong Deng, Zheng Guo, Shuai Shao, Boting Xu   +5 more
doaj   +1 more source

Stability of Transonic Shock Solutions for One-Dimensional Euler-Poisson Equations

, 2010
In this paper, both structural and dynamical stabilities of steady transonic shock solutions for one-dimensional Euler-Poission system are investigated.
B. Zhang, C.V. Pao, Chunjing Xie, D. Wang, D.P. Chen, F. Huang, G.-Q. Chen, G.Q. Chen, H. Li, I.M. Gamba, I.M. Gamba, J. Li, J. Li, J. Rauch, J. Rauch, J. Rauch, Jeffrey Rauch, M.D. Rosini, M.D. Rosini, P. Degond, P. Degond, P. Embid, P.A. Markowich, P.A. Markowich, S.-Y. Ha, S.-Y. Ha, T. Luo, T.P. Liu, T.P. Liu, T.P. Liu, Tao Luo, U.M. Ascher, W.-C. Lien, Y.-J. Peng, Z. Xin, Z. Xin, Zhouping Xin   +36 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Calculation of transonic flows around profiles with blunt and angled leading edges

Vietnam Journal of Mechanics, 2016
Transonic flow is a mixed flow of subsonic and supersonic regions. Because of this mixture, the solution of transonic flow problems is obtained only when solving the differential equations of motion with special treatments for the transition from ...
Hoang Thi Bich Ngoc, Nguyen Manh Hung
doaj   +1 more source

Receptivity and Stability Theory Analysis of a Transonic Swept Wing Experiment

Aerospace, 2023
Surface suction provides an efficient way to delay boundary layer transitions. In order to verify the suction effects and determine the mechanism of suction control in transonic swept wing boundary layers, wind tunnel transition measurements in a hybrid ...
Yuanqiang Liu, Yan Liu, Zubi Ji, Yutian Wang, Jiakuan Xu   +4 more
doaj   +1 more source

Advection-dominated accretion flows with causal viscosity [PDF]

, 2006
We present the basic equations and sample solutions for the steady-state global transonic solutions of the advection-dominated accretion flows (ADAFs) with a causal viscosity prescription.
Abramowicz, Acrobat, Becker, Gammie, Lu, Narayan, Paczynski, Papaloizou, R. Takahashi   +8 more
core   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Sensitivity analysis and multi-objective robust design optimization of compact aero-engine nacelles

Engineering Applications of Computational Fluid Mechanics
Future civil aero-engines are expected to feature larger bypass ratios and fan diameters to reduce specific thrust and improve propulsive efficiency, thereby lowering specific fuel consumption. These new configurations introduce design challenges, as the
Guocheng Tao, Yang Liu, Zhouteng Ye, Chengwei Fan, Yanzhao Gong, Yan Yan, Jiahuan Cui   +6 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source