Results 81 to 90 of about 1,296,795 (347)
Spermatogonial stem cell transplantation provides a unique opportunity to study the biology of spermatogenesis and also offers an alternative approach for genetic modification in large animals.
A SHARMA+9 more
doaj +1 more source
MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation [PDF]
Lung transplantation remains the only viable treatment option for the majority of patients with advanced lung diseases. However, 5-year post-transplant survival rates remain low primarily secondary to chronic rejection. Novel insights from global gene expression profiles may provide molecular phenotypes and therapeutic targets to improve outcomes after
arxiv +1 more source
Accelerated coronary artery disease has become a major complication to heart transplantation in humans. Therefore, we have developed a surgical model in the rabbit, with transplantation of the thoracic aorta as a bypass graft onto the abdominal aorta of ...
E. Hjelms, S. Stender
semanticscholar +1 more source
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf+7 more
wiley +1 more source
Cold ischemia or topical-ECMO for lung preservation: a randomized experimental study
CONTEXT AND OBJECTIVE: Lung preservation remains a challenging issue for lung transplantation groups. Along with the development of ex vivo lung perfusion, a new preservation method known as topical-ECMO (extracorporal membrane oxygenation) has been ...
Alessandro Wasum Mariani+8 more
doaj +1 more source
Inhibitory effect of rapamycin-deep eutectic solvent eye drops on corneal allograft rejection in mice and its mechanism [PDF]
Objective To investigate the inhibitory effect of rapamycin (RAPA)-deep eutectic solvent (DES) eye drops on corneal allograft rejection in mice and its mechanism.
YANG Yang, HUANG Cixin, ZENG Fanxing, SUN Yaru, WEI Chao, WANG Hongwei, GAO Hua
doaj +1 more source
Enhancing kidney transplantation through multi-agent kidney exchange programs: A comprehensive review and optimization models [PDF]
This paper presents a comprehensive review of the last two decades of research on Kidney Exchange Programs (KEPs), systematically categorizing and classifying key contributions to provide readers with a structured understanding of advancements in the field.
arxiv +1 more source
Pregnancy following homologous prepubertal ovarian transplantation in the dog [PDF]
In several canine models of hereditary human disease the homozygote dogs die prior to puberty, or have substantially reduced fertility. To create a clinically healthy animal that can be bred, but can also transmit the gene of interest, a model of homologous ovarian transplantation in prepubertal dogs was developed.
Jennifer K Pullium+3 more
openaire +3 more sources
Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy
This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan+11 more
wiley +1 more source
Fresh osteochondral knee allografts in Brazil with a minimum two-year follow-up
OBJECTIVE: The present study aimed to report the results of the first series of cases of fresh ostechondral allografts in the knee joint in Brazil with a minimum follow-up of two years.
Luís Eduardo Passarelli Tírico+5 more
doaj +1 more source